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Table 6 Logistic analysis of the association between SNPs rs4977574 and rs1333045 and CHD risk

From: Analysis on the polymorphisms of site RS4977574, and RS1333045 in region 9p21 and the susceptibility of coronary heart disease in Chinese population

Rs4977574 (A > G)CHD (n = 598)Control (n = 257)OR(95% CI)P valueAOR*(95% CI)P* value
AA149871.000 (reference)0.0121.000 (reference)0.005
AG2971221.849 (1.217–2.810)0.0042.035 (1.323–3.132)0.001
GG152481.421 (1.014–1.993)0.0421.452 (1.026–2.054)0.035
Dominant model (AAvsAG+GG)149/44987/1701.542 (1.122–2.119)0.0081.612(1.163–2.235)0.004
Recessive model (GGvsAA+AG)152/44648/2090.674 (0.468–0.970)0.0330.620 (0.427–0.902)0.012
Allele A frequency595 (49.75%)296 (57.59%)OR(95% CI)P valueAOR*(95% CI)P* value
Allele G frequency601 (50.25%)218 (42.41%)    
HWE0.8710.651    
RS1333045 (C > T)CHD (n = 598)Control (n = 257)    
CC168571.000 (reference)0.1081.000 (reference)0.060
TC2921270.641 (0.424–0.970)0.0350.599 (0.392–0.915)0.018
TT138730.780 (0.541–1.124)0.1830.759 (0.522–1.105)0.151
Dominant model (CCvsTC+TT)168/43057/2000.729 (0.517–1.029)0.0720.700 (0.492–0.997)0.048
Recessive model (TTvsCC+TC)138/46073/1841.322 (0.950–1.842)0.0981.392 (0.991–1.955)0.057
Allele C frequency628 (52.51%)241 (46.89%)    
Allele T frequency568 (47.49%)273 (53.11%)    
HWE0.6090.900    
  1. In the SNP rs4977574, GG represents the homozygote of minor alleles, AG represents the heterozygote, and AA represents the homozygote of major alleles. In the SNP rs1333045, TT represents the homozygote of minor alleles, TC represents the heterozygote, and CC represents the homozygote of major alleles
  2. AOR Adjusted odds ratio
  3. *Adjusted for age and gender