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Table 4 Meta-analysis of TNF-α 857C/T polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic ModelSubgroup analysisN (case/control)OR(95%CI)P*I2P#P value
BeggEgger
TT vs CC + CT
 overall3494/52791.124 (0.836,1.510)0.4370.0%0.4401.0000.769
European2139/35661.135 (0.753,1.710)0.7520.0%0.5460.6240.577
North Asian1158/13091.112 (0.726,1.703)0.13243.5%0.6270.6240.994
HWE1844/30781.230 (0.866,1.748)0.4660.0%0.2470.8810.960
NO HWE1453/17970.901 (0.519,1.564)0.30515.9%0.7110.6020.839
TT + CT vs CC
 overall3494/52790.920 (0.825,1.027)0.3579.2%0.1370.2830.467
European2139/35660.978 (0.851,1.125)0.4980.0%0.7580.3270.810
North Asian1158/13090.835 (0.701,0.996)0.32713.7%0.0450.6240.992
HWE1844/30780.909 (0.793,1.041)0.23026.1%0.1670.8810.641
NO HWE1453/17970.942 (0.784,1.132)0.4280.0%0.5240.1170.006
TT vs CC
 overall3494/52791.105 (0.820,1.488)0.3688.0%0.5130.8580.833
European2139/35661.140 (0.755,1.721)0.7040.0%0.5340.6240.643
North Asian1158/13091.067 (0.693,1.644)0.10947.1%0.7670.6240.972
HWE1844/30781.209 (0.848,1.724)0.3835.8%0.2950.8810.996
NO HWE1453/17970.890 (0.511,1.547)0.29119.1%0.6790.6020.872
CT vs CC
 overall3494/52790.904 (0.807,1.012)0.6050.0%0.0810.4740.429
European2139/35660.966 (0.836,1.116)0.6100.0%0.6370.3270.689
North Asian1158/13090.812 (0.676,0.976)0.6490.0%0.0261.0000.695
HWE1844/30780.881 (0.765,1.015)0.4660.0%0.0800.6520.632
NO HWE1453/17970.946 (0.782,1.145)0.5130.0%0.5690.6020.247
T vs C
 overall3494/52790.949 (0.862,1.045)0.18128.6%0.2880.3710.496
European2139/35660.994 (0.878,1.126)0.4420.0%0.9260.6240.901
North Asian1158/13090.886 (0.762,1.032)0.10847.2%0.1191.0000.718
HWE1844/30780.952 (0.846,1.071)0.10942.2%0.4160.6520.796
NO HWE1453/17970.943 (0.798,1.114)0.3309.7%0.4900.1170.223
  1. *P value of Heterogeneity chi-squared
  2. #P value of Pooled statistic