Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Huang, Rui; Zhao, Su-Rui; Li, Ya; Liu, Fang; Gong, Yue; Xing, Jun; Xu, Ze-Sheng

doi:10.1186/s12881-020-0952-2

Table 4 Meta-analysis of TNF-α 857C/T polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic Model	Subgroup analysis	N (case/control)	OR(95%CI)	P*	I2	P#	P value
Genetic Model	Subgroup analysis	N (case/control)	OR(95%CI)	P*	I2	P#	Begg	Egger
TT vs CC + CT
	overall	3494/5279	1.124 (0.836,1.510)	0.437	0.0%	0.440	1.000	0.769
	European	2139/3566	1.135 (0.753,1.710)	0.752	0.0%	0.546	0.624	0.577
	North Asian	1158/1309	1.112 (0.726,1.703)	0.132	43.5%	0.627	0.624	0.994
	HWE	1844/3078	1.230 (0.866,1.748)	0.466	0.0%	0.247	0.881	0.960
	NO HWE	1453/1797	0.901 (0.519,1.564)	0.305	15.9%	0.711	0.602	0.839
TT + CT vs CC
	overall	3494/5279	0.920 (0.825,1.027)	0.357	9.2%	0.137	0.283	0.467
	European	2139/3566	0.978 (0.851,1.125)	0.498	0.0%	0.758	0.327	0.810
	North Asian	1158/1309	0.835 (0.701,0.996)	0.327	13.7%	0.045	0.624	0.992
	HWE	1844/3078	0.909 (0.793,1.041)	0.230	26.1%	0.167	0.881	0.641
	NO HWE	1453/1797	0.942 (0.784,1.132)	0.428	0.0%	0.524	0.117	0.006
TT vs CC
	overall	3494/5279	1.105 (0.820,1.488)	0.368	8.0%	0.513	0.858	0.833
	European	2139/3566	1.140 (0.755,1.721)	0.704	0.0%	0.534	0.624	0.643
	North Asian	1158/1309	1.067 (0.693,1.644)	0.109	47.1%	0.767	0.624	0.972
	HWE	1844/3078	1.209 (0.848,1.724)	0.383	5.8%	0.295	0.881	0.996
	NO HWE	1453/1797	0.890 (0.511,1.547)	0.291	19.1%	0.679	0.602	0.872
CT vs CC
	overall	3494/5279	0.904 (0.807,1.012)	0.605	0.0%	0.081	0.474	0.429
	European	2139/3566	0.966 (0.836,1.116)	0.610	0.0%	0.637	0.327	0.689
	North Asian	1158/1309	0.812 (0.676,0.976)	0.649	0.0%	0.026	1.000	0.695
	HWE	1844/3078	0.881 (0.765,1.015)	0.466	0.0%	0.080	0.652	0.632
	NO HWE	1453/1797	0.946 (0.782,1.145)	0.513	0.0%	0.569	0.602	0.247
T vs C
	overall	3494/5279	0.949 (0.862,1.045)	0.181	28.6%	0.288	0.371	0.496
	European	2139/3566	0.994 (0.878,1.126)	0.442	0.0%	0.926	0.624	0.901
	North Asian	1158/1309	0.886 (0.762,1.032)	0.108	47.2%	0.119	1.000	0.718
	HWE	1844/3078	0.952 (0.846,1.071)	0.109	42.2%	0.416	0.652	0.796
	NO HWE	1453/1797	0.943 (0.798,1.114)	0.330	9.7%	0.490	0.117	0.223

*P value of Heterogeneity chi-squared
#P value of Pooled statistic

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