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Table 3 Meta-analysis of TNF-α 238G/A polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic ModelSubgroup analysisN (case/control)OR(95%CI)P*I2P#P value
BeggEgger
AA vs GG + GA
 overall4827/68751.478 (0.821,2.662)0.6240.0%0.1930.1610.034
European2108/36862.985 (1.121,7.946)0.6910.0%0.2090.6240.902
North Asian2522/27850.947 (0.443,2.023)0.6590.0%0.8880.1880.038
HWE3934/59412.832 (1.258,6.375)0.9030.0%0.0120.6770.848
NO HWE696/5300.602 (0.236,1.537)0.7210.0%0.2890.317
AA+GA vs GG
 overall4827/68751.072 (0.931,1.235)0.03346.6%0.3310.3000.041
European2108/36860.929 (0.758,1.138)0.3755.6%0.4750.3270.440
North Asian2522/27851.231 (1.010,1.500)0.04451.5%0.0400.6210.148
HWE3934/59411.020 (0.879,1.184)0.05245.0%0.7910.1860.110
NO HWE696/5301.686 (1.060,2.681)0.5860.0%0.0270.317
AA vs GG
 overall4827/68751.506 (0.835,2.715)0.6580.0%0.1730.1610.033
European2108/36862.961 (1.113,7.879)0.6910.0%0.0300.6240.927
North Asian2522/27850.980 (0.458,2.097)0.6800.0%0.9580.1880.037
HWE3934/59412.838 (1.260,6.394)0.9340.0%0.0120.6770.893
NO HWE696/5300.629 (0.246,1.608)0.7050.0%0.3330.317
GA vs GG
 overall4827/68751.165 (0.914,1.485)0.00756.2%0.2180.1000.040
European2108/36860.890 (0.706,1.121)0.34311.1%0.3220.3270.391
North Asian2522/27851.409 (0.981,2.024)0.01460.2%0.0630.8050.160
HWE3934/59411.053 (0.837,1.325)0.03947.6%0.6590.1860.156
NO HWE696/5302.265 (1.307,3.926)0.6510.0%0.0040.317
A vs G
 overall4827/68751.088 (0.950,1.244)0.09635.8%0.2220.2460.040
European2108/36860.979 (0.807,1.189)0.4160.0%0.8330.1420.509
North Asian2522/27851.201 (0.995,1.450)0.08444.1%0.0570.8050.117
HWE3934/59411.055 (0.914,1.217)0.07740.7%0.4650.2430.087
NO HWE696/5301.377 (0.918,2.065)0.5380.0%0.1220.317
  1. *P value of Heterogeneity chi-squared
  2. #P value of Pooled statistic