Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Huang, Rui; Zhao, Su-Rui; Li, Ya; Liu, Fang; Gong, Yue; Xing, Jun; Xu, Ze-Sheng

doi:10.1186/s12881-020-0952-2

Table 3 Meta-analysis of TNF-α 238G/A polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic Model	Subgroup analysis	N (case/control)	OR(95%CI)	P*	I2	P#	P value
Genetic Model	Subgroup analysis	N (case/control)	OR(95%CI)	P*	I2	P#	Begg	Egger
AA vs GG + GA
	overall	4827/6875	1.478 (0.821,2.662)	0.624	0.0%	0.193	0.161	0.034
	European	2108/3686	2.985 (1.121,7.946)	0.691	0.0%	0.209	0.624	0.902
	North Asian	2522/2785	0.947 (0.443,2.023)	0.659	0.0%	0.888	0.188	0.038
	HWE	3934/5941	2.832 (1.258,6.375)	0.903	0.0%	0.012	0.677	0.848
	NO HWE	696/530	0.602 (0.236,1.537)	0.721	0.0%	0.289	0.317	–
AA+GA vs GG
	overall	4827/6875	1.072 (0.931,1.235)	0.033	46.6%	0.331	0.300	0.041
	European	2108/3686	0.929 (0.758,1.138)	0.375	5.6%	0.475	0.327	0.440
	North Asian	2522/2785	1.231 (1.010,1.500)	0.044	51.5%	0.040	0.621	0.148
	HWE	3934/5941	1.020 (0.879,1.184)	0.052	45.0%	0.791	0.186	0.110
	NO HWE	696/530	1.686 (1.060,2.681)	0.586	0.0%	0.027	0.317	–
AA vs GG
	overall	4827/6875	1.506 (0.835,2.715)	0.658	0.0%	0.173	0.161	0.033
	European	2108/3686	2.961 (1.113,7.879)	0.691	0.0%	0.030	0.624	0.927
	North Asian	2522/2785	0.980 (0.458,2.097)	0.680	0.0%	0.958	0.188	0.037
	HWE	3934/5941	2.838 (1.260,6.394)	0.934	0.0%	0.012	0.677	0.893
	NO HWE	696/530	0.629 (0.246,1.608)	0.705	0.0%	0.333	0.317	–
GA vs GG
	overall	4827/6875	1.165 (0.914,1.485)	0.007	56.2%	0.218	0.100	0.040
	European	2108/3686	0.890 (0.706,1.121)	0.343	11.1%	0.322	0.327	0.391
	North Asian	2522/2785	1.409 (0.981,2.024)	0.014	60.2%	0.063	0.805	0.160
	HWE	3934/5941	1.053 (0.837,1.325)	0.039	47.6%	0.659	0.186	0.156
	NO HWE	696/530	2.265 (1.307,3.926)	0.651	0.0%	0.004	0.317	–
A vs G
	overall	4827/6875	1.088 (0.950,1.244)	0.096	35.8%	0.222	0.246	0.040
	European	2108/3686	0.979 (0.807,1.189)	0.416	0.0%	0.833	0.142	0.509
	North Asian	2522/2785	1.201 (0.995,1.450)	0.084	44.1%	0.057	0.805	0.117
	HWE	3934/5941	1.055 (0.914,1.217)	0.077	40.7%	0.465	0.243	0.087
	NO HWE	696/530	1.377 (0.918,2.065)	0.538	0.0%	0.122	0.317	–

^*P value of Heterogeneity chi-squared
^#P value of Pooled statistic

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