Genetic Model | Subgroup analysis | N (case/control) | OR(95% CI) | P* | I2 | P# | P value | |
---|---|---|---|---|---|---|---|---|
Begg | Egger | |||||||
AA vs GG + GA | ||||||||
overall | 6522/8196 | 1.102 (0.886,1.370) | 0.209 | 22.0% | 0.383 | 0.322 | 0.106 | |
European | 2472/4076 | 1.118 (0.810,1.544) | 0.087 | 45.7% | 0.496 | 0.881 | 0.102 | |
North Asian | 3322/3332 | 1.135 (0.821,1.570) | 0.349 | 10.0% | 0.443 | 0.624 | 0.907 | |
African | 418/406 | 0.705 (0.320,1.553) | – | – | 0.385 | – | – | |
South Asian | 310/382 | 3.880 (0.401,37.525) | 0.894 | 0.0% | 0.242 | 0.317 | – | |
HWE | 5814/7737 | 1.096 (0.835,1.438) | 0.210 | 23.1% | 0.510 | 0.329 | 0.042 | |
NO HWE | 708/459 | 1.112 (0.773,1.601) | 0.127 | 57.1% | 0.567 | 0.317 | – | |
AA+GA vs GG | ||||||||
overall | 6522/8196 | 1.046(0.963,1.136) | 0.151 | 24.8% | 0.290 | 0.770 | 0.973 | |
European | 2472/4076 | 1.008 (0.899,1.130) | 0.390 | 4.8% | 0.890 | 0.881 | 0.804 | |
North Asian | 3322/3332 | 1.065 (0.927,1.222) | 0.143 | 33.1% | 0.374 | 0.128 | 0.138 | |
African | 418/406 | 1.109 (0.833,1.476) | – | – | 0.478 | – | – | |
South Asian | 310/382 | 1.352 (0.839,2.179) | 0.046 | 74.8% | 0.216 | 0.317 | – | |
HWE | 5814/7737 | 1.033 (0.948,1.126) | 0.175 | 23.6% | 0.459 | 0.791 | 0.972 | |
NO HWE | 708/459 | 1.219 (0.896,1.658) | 0.152 | 51.3% | 0.208 | 0.317 | – | |
AA vs GG | ||||||||
overall | 6522/8196 | 1.106 (0.888,1.377) | 0.226 | 20.5% | 0.367 | 0.373 | 0.132 | |
European | 2472/4076 | 1.105 (0.798,1.530) | 0.118 | 41.0% | 0.548 | 0.453 | 0.097 | |
North Asian | 3322/3332 | 1.147 (0.829,1.587) | 0.274 | 22.1% | 0.407 | 0.624 | 0.822 | |
African | 418/406 | 0.739 (0.333,1.638) | – | – | 0.456 | – | – | |
South Asian | 310/382 | 4.018 (0.415,38.903) | 0.869 | 0.0% | 0.230 | 0.317 | – | |
HWE | 5814/7737 | 1.088 (0.828,1.431) | 0.234 | 20.8% | 0.545 | 0.329 | 0.048 | |
NO HWE | 708/459 | 1.138 (0.790,1.641) | 0.121 | 58.5% | 0.488 | 0.317 | – | |
GA vs GG | ||||||||
overall | 6522/8196 | 1.037 (0.950,1.131) | 0.258 | 15.7% | 0.418 | 0.673 | 0.958 | |
European | 2472/4076 | 0.999 (0.887,1.124) | 0.352 | 10.1% | 0.981 | 0.881 | 0.707 | |
North Asian | 3322/3332 | 1.049 (0.903,1.218) | 0.288 | 16.9% | 0.531 | 0.531 | 0.398 | |
African | 418/406 | 1.154 (0.859,1.549) | – | – | 0.179 | – | – | |
South Asian | 310/382 | 1.281 (0.790,2.076) | 0.061 | 71.4% | 0.315 | 0.317 | – | |
HWE | 5814/7737 | 1.027 (0.940,1.122) | 0.226 | 19.1% | 0.557 | 0.850 | 0.671 | |
NO HWE | 708/459 | 1.389 (0.839,2.298) | 0.641 | 0.0% | 0.201 | 0.317 | – | |
A vs G | ||||||||
overall | 6522/8196 | 1.047 (0.973,1.126) | 0.065 | 34.7% | 0.222 | 0.721 | 0.673 | |
European | 2472/4076 | 1.017 (0.920,1.124) | 0.303 | 16.6% | 0.741 | 0.453 | 0.312 | |
North Asian | 3322/3332 | 1.071 (0.947,1.211) | 0.071 | 43.1% | 0.276 | 0.128 | 0.120 | |
African | 418/406 | 1.043 (0.816,1.332) | – | – | 0.636 | – | – | |
South Asian | 310/382 | 1.400 (0.887,2.210) | 0.037 | 77.0% | 0.149 | 0.317 | – | |
HWE | 5814/7737 | 1.034 (0.957,1.116) | 0.122 | 28.9% | 0.399 | 0.850 | 0.628 | |
NO HWE | 708/459 | 1.172 (0.927,1.481) | 0.039 | 76.6% | 0.185 | 0.317 | – |