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Table 2 Meta-analysis of TNF-α 308G/A polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic Model

Subgroup analysis

N (case/control)

OR(95% CI)

P*

I2

P#

P value

Begg

Egger

AA vs GG + GA

 

overall

6522/8196

1.102 (0.886,1.370)

0.209

22.0%

0.383

0.322

0.106

European

2472/4076

1.118 (0.810,1.544)

0.087

45.7%

0.496

0.881

0.102

North Asian

3322/3332

1.135 (0.821,1.570)

0.349

10.0%

0.443

0.624

0.907

African

418/406

0.705 (0.320,1.553)

0.385

South Asian

310/382

3.880 (0.401,37.525)

0.894

0.0%

0.242

0.317

HWE

5814/7737

1.096 (0.835,1.438)

0.210

23.1%

0.510

0.329

0.042

NO HWE

708/459

1.112 (0.773,1.601)

0.127

57.1%

0.567

0.317

AA+GA vs GG

 

overall

6522/8196

1.046(0.963,1.136)

0.151

24.8%

0.290

0.770

0.973

European

2472/4076

1.008 (0.899,1.130)

0.390

4.8%

0.890

0.881

0.804

North Asian

3322/3332

1.065 (0.927,1.222)

0.143

33.1%

0.374

0.128

0.138

African

418/406

1.109 (0.833,1.476)

0.478

South Asian

310/382

1.352 (0.839,2.179)

0.046

74.8%

0.216

0.317

HWE

5814/7737

1.033 (0.948,1.126)

0.175

23.6%

0.459

0.791

0.972

NO HWE

708/459

1.219 (0.896,1.658)

0.152

51.3%

0.208

0.317

AA vs GG

 

overall

6522/8196

1.106 (0.888,1.377)

0.226

20.5%

0.367

0.373

0.132

European

2472/4076

1.105 (0.798,1.530)

0.118

41.0%

0.548

0.453

0.097

North Asian

3322/3332

1.147 (0.829,1.587)

0.274

22.1%

0.407

0.624

0.822

African

418/406

0.739 (0.333,1.638)

0.456

South Asian

310/382

4.018 (0.415,38.903)

0.869

0.0%

0.230

0.317

HWE

5814/7737

1.088 (0.828,1.431)

0.234

20.8%

0.545

0.329

0.048

NO HWE

708/459

1.138 (0.790,1.641)

0.121

58.5%

0.488

0.317

GA vs GG

 

overall

6522/8196

1.037 (0.950,1.131)

0.258

15.7%

0.418

0.673

0.958

European

2472/4076

0.999 (0.887,1.124)

0.352

10.1%

0.981

0.881

0.707

North Asian

3322/3332

1.049 (0.903,1.218)

0.288

16.9%

0.531

0.531

0.398

African

418/406

1.154 (0.859,1.549)

0.179

South Asian

310/382

1.281 (0.790,2.076)

0.061

71.4%

0.315

0.317

HWE

5814/7737

1.027 (0.940,1.122)

0.226

19.1%

0.557

0.850

0.671

NO HWE

708/459

1.389 (0.839,2.298)

0.641

0.0%

0.201

0.317

A vs G

 

overall

6522/8196

1.047 (0.973,1.126)

0.065

34.7%

0.222

0.721

0.673

European

2472/4076

1.017 (0.920,1.124)

0.303

16.6%

0.741

0.453

0.312

North Asian

3322/3332

1.071 (0.947,1.211)

0.071

43.1%

0.276

0.128

0.120

African

418/406

1.043 (0.816,1.332)

0.636

South Asian

310/382

1.400 (0.887,2.210)

0.037

77.0%

0.149

0.317

HWE

5814/7737

1.034 (0.957,1.116)

0.122

28.9%

0.399

0.850

0.628

NO HWE

708/459

1.172 (0.927,1.481)

0.039

76.6%

0.185

0.317

  1. *P value of Heterogeneity chi-squared
  2. #P value of Pooled statistic