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Table 2 Meta-analysis of TNF-α 308G/A polymorphisms and CAD susceptibility

From: Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Genetic ModelSubgroup analysisN (case/control)OR(95% CI)P*I2P#P value
BeggEgger
AA vs GG + GA
 overall6522/81961.102 (0.886,1.370)0.20922.0%0.3830.3220.106
European2472/40761.118 (0.810,1.544)0.08745.7%0.4960.8810.102
North Asian3322/33321.135 (0.821,1.570)0.34910.0%0.4430.6240.907
African418/4060.705 (0.320,1.553)0.385
South Asian310/3823.880 (0.401,37.525)0.8940.0%0.2420.317
HWE5814/77371.096 (0.835,1.438)0.21023.1%0.5100.3290.042
NO HWE708/4591.112 (0.773,1.601)0.12757.1%0.5670.317
AA+GA vs GG
 overall6522/81961.046(0.963,1.136)0.15124.8%0.2900.7700.973
European2472/40761.008 (0.899,1.130)0.3904.8%0.8900.8810.804
North Asian3322/33321.065 (0.927,1.222)0.14333.1%0.3740.1280.138
African418/4061.109 (0.833,1.476)0.478
South Asian310/3821.352 (0.839,2.179)0.04674.8%0.2160.317
HWE5814/77371.033 (0.948,1.126)0.17523.6%0.4590.7910.972
NO HWE708/4591.219 (0.896,1.658)0.15251.3%0.2080.317
AA vs GG
 overall6522/81961.106 (0.888,1.377)0.22620.5%0.3670.3730.132
European2472/40761.105 (0.798,1.530)0.11841.0%0.5480.4530.097
North Asian3322/33321.147 (0.829,1.587)0.27422.1%0.4070.6240.822
African418/4060.739 (0.333,1.638)0.456
South Asian310/3824.018 (0.415,38.903)0.8690.0%0.2300.317
HWE5814/77371.088 (0.828,1.431)0.23420.8%0.5450.3290.048
NO HWE708/4591.138 (0.790,1.641)0.12158.5%0.4880.317
GA vs GG
 overall6522/81961.037 (0.950,1.131)0.25815.7%0.4180.6730.958
European2472/40760.999 (0.887,1.124)0.35210.1%0.9810.8810.707
North Asian3322/33321.049 (0.903,1.218)0.28816.9%0.5310.5310.398
African418/4061.154 (0.859,1.549)0.179
South Asian310/3821.281 (0.790,2.076)0.06171.4%0.3150.317
HWE5814/77371.027 (0.940,1.122)0.22619.1%0.5570.8500.671
NO HWE708/4591.389 (0.839,2.298)0.6410.0%0.2010.317
A vs G
 overall6522/81961.047 (0.973,1.126)0.06534.7%0.2220.7210.673
European2472/40761.017 (0.920,1.124)0.30316.6%0.7410.4530.312
North Asian3322/33321.071 (0.947,1.211)0.07143.1%0.2760.1280.120
African418/4061.043 (0.816,1.332)0.636
South Asian310/3821.400 (0.887,2.210)0.03777.0%0.1490.317
HWE5814/77371.034 (0.957,1.116)0.12228.9%0.3990.8500.628
NO HWE708/4591.172 (0.927,1.481)0.03976.6%0.1850.317
  1. *P value of Heterogeneity chi-squared
  2. #P value of Pooled statistic