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Table 1 Numbers of significantly differential expressed metabolites (DEM) (P < 0.05, VIP > 1.0)

From: Familial autosomal recessive bestrophinopathy: identification of a novel variant in BEST1 gene and the specific metabolomic profile

Comparison

Total metabolites (n)

DEM (n)

Up-regulated DEM (n)

Down-regulated DEM (n)

Fold change > 1.2

 A_A.vs.G_G_pos

990

16

8

8

 A_G.vs.G_G_pos

990

24

17

7

 A_A.vs.A_G_pos

990

18

14

4

 A_A.vs.G_G_neg

670

25

3

22

 A_G.vs.G_G_neg

670

19

6

13

 A_A.vs.A_G_neg

670

14

4

10

Fold change > 2.0

 A_A.vs.G_G_pos

990

10

5

5

 A_G.vs.G_G_pos

990

15

11

4

 A_A.vs.A_G_pos

990

9

5

4

 A_A.vs.G_G_neg

670

23

1

22

 A_G.vs.G_G_neg

670

5

3

2

 A_A.vs.A_G_neg

670

12

3

9