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Table 3 Determination of Genetic Risk Score based on Allele test of CHB susceptible loci

From: A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population

Gene/Marker Genotype distribution Allele test GRSb
CHB (n = 955) PC (n = 761) Allelea OR (95% CI) P-value
CFB/rs12614 CC(829) CC(550) C 1 1
CT(91) CT(142) T 0.44 (0.33–0.57) 6.46 × 10− 10 0.44
TT(3) TT(7)     0.22
HLA-DPB1/rs9277535c GG(420) GG(184) G 1 1
GA(428) GA(384) A 0.49 (0.43–0.56) 9.47 × 10−24 0.49
AA(107) AA(193)     0.25
HLA-DPA1/rs3077c GG(489) GG(221) G 1 1
GA(382) GA(385) A 0.48 (0.41–0.55) 1.84 × 10−24 0.48
AA(84) AA(155)     0.24
HLA-DQB1/rs2856718c CC(226) CC(263) C 1 1
CT(418) CT(373) T 1.72 (1.50–1.97) 3.10 × 10−15 1.72
TT(311) TT(125)     3.44
HLA-DQB2/rs7453920c GG(743) GG(461) G 1 1
GA(196) GA(275) A 0.49 (0.41–0.60) 1.07 × 10−13 0.49
AA(16) AA(25)     0.25
TCF19/rs1419881c TT(419) TT(270) T 1 1
TC(424) TC(361) C 0.74 (0.64–0.85) 3.46 × 10−5 0.74
CC(112) CC(130)     0.37
EHMT2/rs652888c TT(610) TT(565) T 1 1
TC(300) TC(188) C 1.65 (1.37–1.99) 5.14 × 10−8 1.65
CC(45) CC(8)     3.3
OCT4/rs1265163c GG(401) GG(392) G 1 1
GC(439) GC(299) C 1.32 (1.14–1.53) 1.36 × 10−4 1.32
CC(114) CC(70)     2.64
EHMT2/rs35875104c TT(878) TT(650) T 1 1
TC(75) TC(108) C 0.53 (0.39–0.71) 2.42 × 10− 5 0.53
CC(2) CC(3)     0.27
VARS2-SFTA/rs9394021c AA(303) AA(189) A 1 1
AG(471) AG(368) G 0.73 (0.64–0.84) 1.10 × 10−5 0.73
GG(177) GG(203)     0.37
VARS2-SFTA/rs2517459c GG(809) GG(560) G 1 1
GA(139) GA(193) A 0.53 (0.43–0.67) 3.71 × 10−8 0.53
AA(6) AA(8)     0.27
  1. Significant associations are shown in bold face (P < 0.05)
  2. CHB chronic hepatitis B, PC population control, OR odds ratio, CI confidence interval, GRS genetic risk score
  3. aMajor and minor alleles were determined in all study subjects
  4. bGRS was calculated by multiplying the number of minor alleles by effect size (OR) of the SNP
  5. cPreviously identified CHB marker in Korean population