|
Gene/Marker
|
Genotype distribution
|
Allele test
|
GRSb
|
|---|
|
CHB (n = 955)
|
PC (n = 761)
|
Allelea
|
OR (95% CI)
|
P-value
|
|---|
|
CFB/rs12614
|
CC(829)
|
CC(550)
|
C
|
1
|
–
|
1
|
|
CT(91)
|
CT(142)
|
T
|
0.44 (0.33–0.57)
|
6.46 × 10− 10
|
0.44
|
|
TT(3)
|
TT(7)
| | | |
0.22
|
|
HLA-DPB1/rs9277535c
|
GG(420)
|
GG(184)
|
G
|
1
|
–
|
1
|
|
GA(428)
|
GA(384)
|
A
|
0.49 (0.43–0.56)
|
9.47 × 10−24
|
0.49
|
|
AA(107)
|
AA(193)
| | | |
0.25
|
|
HLA-DPA1/rs3077c
|
GG(489)
|
GG(221)
|
G
|
1
|
–
|
1
|
|
GA(382)
|
GA(385)
|
A
|
0.48 (0.41–0.55)
|
1.84 × 10−24
|
0.48
|
|
AA(84)
|
AA(155)
| | | |
0.24
|
|
HLA-DQB1/rs2856718c
|
CC(226)
|
CC(263)
|
C
|
1
|
–
|
1
|
|
CT(418)
|
CT(373)
|
T
|
1.72 (1.50–1.97)
|
3.10 × 10−15
|
1.72
|
|
TT(311)
|
TT(125)
| | | |
3.44
|
|
HLA-DQB2/rs7453920c
|
GG(743)
|
GG(461)
|
G
|
1
|
–
|
1
|
|
GA(196)
|
GA(275)
|
A
|
0.49 (0.41–0.60)
|
1.07 × 10−13
|
0.49
|
|
AA(16)
|
AA(25)
| | | |
0.25
|
|
TCF19/rs1419881c
|
TT(419)
|
TT(270)
|
T
|
1
|
–
|
1
|
|
TC(424)
|
TC(361)
|
C
|
0.74 (0.64–0.85)
|
3.46 × 10−5
|
0.74
|
|
CC(112)
|
CC(130)
| | | |
0.37
|
|
EHMT2/rs652888c
|
TT(610)
|
TT(565)
|
T
|
1
|
–
|
1
|
|
TC(300)
|
TC(188)
|
C
|
1.65 (1.37–1.99)
|
5.14 × 10−8
|
1.65
|
|
CC(45)
|
CC(8)
| | | |
3.3
|
|
OCT4/rs1265163c
|
GG(401)
|
GG(392)
|
G
|
1
|
–
|
1
|
|
GC(439)
|
GC(299)
|
C
|
1.32 (1.14–1.53)
|
1.36 × 10−4
|
1.32
|
|
CC(114)
|
CC(70)
| | | |
2.64
|
|
EHMT2/rs35875104c
|
TT(878)
|
TT(650)
|
T
|
1
|
–
|
1
|
|
TC(75)
|
TC(108)
|
C
|
0.53 (0.39–0.71)
|
2.42 × 10− 5
|
0.53
|
|
CC(2)
|
CC(3)
| | | |
0.27
|
|
VARS2-SFTA/rs9394021c
|
AA(303)
|
AA(189)
|
A
|
1
|
–
|
1
|
|
AG(471)
|
AG(368)
|
G
|
0.73 (0.64–0.84)
|
1.10 × 10−5
|
0.73
|
|
GG(177)
|
GG(203)
| | | |
0.37
|
|
VARS2-SFTA/rs2517459c
|
GG(809)
|
GG(560)
|
G
|
1
|
–
|
1
|
|
GA(139)
|
GA(193)
|
A
|
0.53 (0.43–0.67)
|
3.71 × 10−8
|
0.53
|
|
AA(6)
|
AA(8)
| | | |
0.27
|
- Significant associations are shown in bold face (P < 0.05)
- CHB chronic hepatitis B, PC population control, OR odds ratio, CI confidence interval, GRS genetic risk score
- aMajor and minor alleles were determined in all study subjects
- bGRS was calculated by multiplying the number of minor alleles by effect size (OR) of the SNP
- cPreviously identified CHB marker in Korean population
