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Table 3 Determination of Genetic Risk Score based on Allele test of CHB susceptible loci

From: A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population

Gene/Marker

Genotype distribution

Allele test

GRSb

CHB (n = 955)

PC (n = 761)

Allelea

OR (95% CI)

P-value

CFB/rs12614

CC(829)

CC(550)

C

1

1

CT(91)

CT(142)

T

0.44 (0.33–0.57)

6.46 × 10− 10

0.44

TT(3)

TT(7)

   

0.22

HLA-DPB1/rs9277535c

GG(420)

GG(184)

G

1

1

GA(428)

GA(384)

A

0.49 (0.43–0.56)

9.47 × 10−24

0.49

AA(107)

AA(193)

   

0.25

HLA-DPA1/rs3077c

GG(489)

GG(221)

G

1

1

GA(382)

GA(385)

A

0.48 (0.41–0.55)

1.84 × 10−24

0.48

AA(84)

AA(155)

   

0.24

HLA-DQB1/rs2856718c

CC(226)

CC(263)

C

1

1

CT(418)

CT(373)

T

1.72 (1.50–1.97)

3.10 × 10−15

1.72

TT(311)

TT(125)

   

3.44

HLA-DQB2/rs7453920c

GG(743)

GG(461)

G

1

1

GA(196)

GA(275)

A

0.49 (0.41–0.60)

1.07 × 10−13

0.49

AA(16)

AA(25)

   

0.25

TCF19/rs1419881c

TT(419)

TT(270)

T

1

1

TC(424)

TC(361)

C

0.74 (0.64–0.85)

3.46 × 10−5

0.74

CC(112)

CC(130)

   

0.37

EHMT2/rs652888c

TT(610)

TT(565)

T

1

1

TC(300)

TC(188)

C

1.65 (1.37–1.99)

5.14 × 10−8

1.65

CC(45)

CC(8)

   

3.3

OCT4/rs1265163c

GG(401)

GG(392)

G

1

1

GC(439)

GC(299)

C

1.32 (1.14–1.53)

1.36 × 10−4

1.32

CC(114)

CC(70)

   

2.64

EHMT2/rs35875104c

TT(878)

TT(650)

T

1

1

TC(75)

TC(108)

C

0.53 (0.39–0.71)

2.42 × 10− 5

0.53

CC(2)

CC(3)

   

0.27

VARS2-SFTA/rs9394021c

AA(303)

AA(189)

A

1

1

AG(471)

AG(368)

G

0.73 (0.64–0.84)

1.10 × 10−5

0.73

GG(177)

GG(203)

   

0.37

VARS2-SFTA/rs2517459c

GG(809)

GG(560)

G

1

1

GA(139)

GA(193)

A

0.53 (0.43–0.67)

3.71 × 10−8

0.53

AA(6)

AA(8)

   

0.27

  1. Significant associations are shown in bold face (P < 0.05)
  2. CHB chronic hepatitis B, PC population control, OR odds ratio, CI confidence interval, GRS genetic risk score
  3. aMajor and minor alleles were determined in all study subjects
  4. bGRS was calculated by multiplying the number of minor alleles by effect size (OR) of the SNP
  5. cPreviously identified CHB marker in Korean population