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Table 1 Association of CFB genetic polymorphisms with the risk of CHB and HCC

From: A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population

Marker

MAF

Comparing groups

   

Total

(n = 1716)

CHB

PC

(n = 761)

CHB vs. PC

HCC (−) vs. PC

HCC (+) vs. PC

HCC (−) vs. HCC (+)

All CHB

(n = 955)

HCC (−)

(n = 659)

HCC (+)

(n = f)

OR (95% CI)

P*

Pcorr**

OR (95% CI)

P*

Pcorr**

OR (95% CI)

P*

Pcorr**

OR (95% CI)

P*

rs4151667

0.018

0.019

0.018

0.022

0.016

1.23 (0.73–2.08)

0.42

–

1.16 (0.65–2.06)

0.61

–

1.41 (0.70–2.80)

0.34

–

0.82 (0.41–1.63)

0.58

rs12614

0.078

0.053

0.054

0.048

0.112

0.43 (0.33–0.57)

5.91 × 10−10

2.36 × 10−8

0.45 (0.33–0.61)

6.60 × 10− 8

2.64 × 10−6

0.39 (0.25–0.60)

3.10 × 10− 6

1.24 × 10−4

1.13 (0.72–1.78)

0.58

rs641153

0.082

0.083

0.086

0.076

0.080

1.04 (0.81–1.33)

0.74

–

1.08 (0.83–1.41)

0.54

–

0.94 (0.66–1.34)

0.75

–

1.14 (0.80–1.62)

0.45

rs117314762

0.015

0.013

0.014

0.010

0.018

0.67 (0.38–1.17)

0.16

–

0.73 (0.40–1.34)

0.31

–

0.54 (0.22–1.32)

0.15

–

1.35 (0.53–3.45)

0.51

rs1048709

0.279

0.269

0.265

0.277

0.293

0.88 (0.76–1.02)

0.11

–

0.86 (0.73–1.02)

0.09

–

0.92 (0.74–1.14)

0.47

–

0.94 (0.75–1.16)

0.58

rs537160

0.333

0.327

0.322

0.340

0.341

0.93 (0.81–1.08)

0.39

–

0.91 (0.77–1.07)

0.26

–

0.99 (0.81–1.21)

0.95

–

0.91 (0.74–1.13)

0.43

rs541862

0.082

0.083

0.086

0.076

0.080

1.04 (0.81–1.33)

0.74

–

1.08 (0.83–1.41)

0.54

–

0.94 (0.66–1.34)

0.75

–

1.14 (0.80–1.62)

0.45

rs4151657

0.323

0.335

0.341

0.321

0.307

1.13 (0.98–1.30)

0.09

–

1.16 (0.99–1.36)

0.06

–

1.06 (0.86–1.30)

0.55

–

1.09 (0.88–1.34)

0.40

rs45484591

0.001

0.001

0.002

0.000

0.001

0.79 (0.11–5.66)

0.82

–

1.15 (0.16–8.22)

0.89

–

–

–

–

–

–

rs2072633

0.477

0.468

0.467

0.471

0.488

0.92 (0.80–1.05)

0.25

–

0.91 (0.79–1.06)

0.26

–

0.93 (0.77–1.13)

0.50

–

0.98 (0.80–1.19)

0.85

  1. Significant associations are shown in bold face (P < 0.05)
  2. MAF minor allele frequency, CHB chronic hepatitis B, HCC hepatocellular carcinoma, OR odds ratio, CI confidence interval
  3. * P-value of logistic regression analysis under additive model by adjusting for sex and age as covariates
  4. **P-value after Bonferroni correction for multiple testing
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BMC Medical Genetics

ISSN: 1471-2350

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