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Table 1 Association of CFB genetic polymorphisms with the risk of CHB and HCC

From: A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population

Marker MAF Comparing groups    
Total
(n = 1716)
CHB PC
(n = 761)
CHB vs. PC HCC (−) vs. PC HCC (+) vs. PC HCC (−) vs. HCC (+)
All CHB
(n = 955)
HCC (−)
(n = 659)
HCC (+)
(n = f)
OR (95% CI) P* Pcorr** OR (95% CI) P* Pcorr** OR (95% CI) P* Pcorr** OR (95% CI) P*
rs4151667 0.018 0.019 0.018 0.022 0.016 1.23 (0.73–2.08) 0.42 1.16 (0.65–2.06) 0.61 1.41 (0.70–2.80) 0.34 0.82 (0.41–1.63) 0.58
rs12614 0.078 0.053 0.054 0.048 0.112 0.43 (0.33–0.57) 5.91 × 10−10 2.36 × 10−8 0.45 (0.33–0.61) 6.60 × 10− 8 2.64 × 10−6 0.39 (0.25–0.60) 3.10 × 10− 6 1.24 × 10−4 1.13 (0.72–1.78) 0.58
rs641153 0.082 0.083 0.086 0.076 0.080 1.04 (0.81–1.33) 0.74 1.08 (0.83–1.41) 0.54 0.94 (0.66–1.34) 0.75 1.14 (0.80–1.62) 0.45
rs117314762 0.015 0.013 0.014 0.010 0.018 0.67 (0.38–1.17) 0.16 0.73 (0.40–1.34) 0.31 0.54 (0.22–1.32) 0.15 1.35 (0.53–3.45) 0.51
rs1048709 0.279 0.269 0.265 0.277 0.293 0.88 (0.76–1.02) 0.11 0.86 (0.73–1.02) 0.09 0.92 (0.74–1.14) 0.47 0.94 (0.75–1.16) 0.58
rs537160 0.333 0.327 0.322 0.340 0.341 0.93 (0.81–1.08) 0.39 0.91 (0.77–1.07) 0.26 0.99 (0.81–1.21) 0.95 0.91 (0.74–1.13) 0.43
rs541862 0.082 0.083 0.086 0.076 0.080 1.04 (0.81–1.33) 0.74 1.08 (0.83–1.41) 0.54 0.94 (0.66–1.34) 0.75 1.14 (0.80–1.62) 0.45
rs4151657 0.323 0.335 0.341 0.321 0.307 1.13 (0.98–1.30) 0.09 1.16 (0.99–1.36) 0.06 1.06 (0.86–1.30) 0.55 1.09 (0.88–1.34) 0.40
rs45484591 0.001 0.001 0.002 0.000 0.001 0.79 (0.11–5.66) 0.82 1.15 (0.16–8.22) 0.89
rs2072633 0.477 0.468 0.467 0.471 0.488 0.92 (0.80–1.05) 0.25 0.91 (0.79–1.06) 0.26 0.93 (0.77–1.13) 0.50 0.98 (0.80–1.19) 0.85
  1. Significant associations are shown in bold face (P < 0.05)
  2. MAF minor allele frequency, CHB chronic hepatitis B, HCC hepatocellular carcinoma, OR odds ratio, CI confidence interval
  3. * P-value of logistic regression analysis under additive model by adjusting for sex and age as covariates
  4. **P-value after Bonferroni correction for multiple testing