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Table 3 Main results of pooled ORs in meta-analysis of IL-4 (C33T) gene polymorphisms

From: Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications

Subgroup   Sample size Test of association Test of heterogeneity Test of publication bias (Begg’s test) Test of publication bias (Egger’s test)
Genetic model Case/Control OR 95% CI (p-value) I2 (%) P z P t P
Overall Dominant model 6587 / 8404 1.15 1.04–1.26 (≤0.001) 20.9 0.16 0.77 0.44 0.90 0.37
  Recessive model 6587 / 8404 1.16 1.06–1.28 ((≤0.001) 0 0.56 2.68 0.001 2.88 0.001
  Allelic model 6587 / 8404 1.14 1.07–1.21 (≤0.001) 27.8 0.08 2.53 0.01 2.39 0.02
  CC vs. TT 6587 / 8404 1.21 1.02–1.43 (0.02) 0 0.58 1.78 0.07 1.57 0.13
  CT vs. TT 6587 / 8404 1.10 1–1.22 (0.05) 20.5 0.17 0.23 0.81 0.56 0.58
Age subgroups
Adults Dominant model 1678 / 3252 1.16 0.97–1.40 (0.10) 0 0.54 −0.98 0.32 −1.43 0.19
  Recessive model 1678 / 3252 1.17 0.99–1.39 (0.06) 0 0.93 2.41 0.01 3.57 0.007
  Allelic model 1678 / 3252 1.14 1.02–1.26 (0.02) 0 0.75 1.01 0.31 1.44 0.18
  CC vs. TT 1678 / 3252 1.22 0.93–1.61 (0.15) 0 0.72 0.83 0.40 0.64 0.54
  CT vs. TT 1678 / 3252 1.09 0.90–1.32 (0.91) 0.2 0.43 −1.16 0.24 −1.72 0.12
Mixed Dominant model 2067 / 1823 1.14 0.96–1.34 (0.13) 55.8 0.02 2.23 0.02 3.47 0.01
  Recessive model 2067 / 1823 1.08 0.84–1.40 (0.53) 0 0.89 −0.49 0.62 0.47 0.67
  Allelic model 2067 / 1823 1.14 1.01–1.29 (0.03) 56.9 0.02 2.72 0.007 3.11 0.02
  CC vs. TT 2067 / 1823 1.10 0.77–1.57 (0.60) 0 0.88 1.47 0.14 2.01 0.13
  CT vs. TT 2067 / 1823 1.13 0.95–1.35 (0.15) 53.7 0.03 2.47 0.01 3.38 0.01
Children Dominant model 2842 / 3333 1.15 0.99–1.34 (0.07) 12.4 0.33 −0.42 0.67 −0.48 0.64
  Recessive model 2842 / 3333 1.18 1.03–1.35 (0.01) 54 0.03 1.24 0.21 2.34 0.05
  Allelic model 2842 / 3333 1.13 1.04–1.24 (≤0.001) 44.6 0.07 0.42 0.67 0.47 0.65
  CC vs. TT 2842 / 3333 1.27 0.97–1.65 (0.08) 42.3 0.09 0.99 0.32 0.97 0.36
  CT vs. TT 2842 / 3333 1.08 0.92–1.26 (0.33) 4.5 0.39 −0.42 0.67 −0.64 0.54
Continent subgroups
Asia Dominant model 3634 / 5371 1.10 0.93–1.130 (0.25) 29.3 0.13 0.81 0.41 1.44 0.17
  Recessive model 3634 / 5371 1.14 1.02–1.26 (0.01) 0 0.56 0.85 0.39 1.24 0.24
  Allelic model 3634 / 5371 1.12 1.03–1.21 (≤0.001) 34.9 0.08 2.31 0.02 2.70 0.01
  CC vs. TT 3634 / 5371 1.08 0.87–1.33 (0.49) 0 0.77 0 1 0.09 0.93
  CT vs. TT 3634 / 5371 1.02 0.89–1.18 (0.76) 29.6 0.12 0.45 0.65 0.93 0.36
Europe Dominant model 1129 / 1008 1.23 1.01–1.50 (0.03) 48.3 0.12 −0.68 0.49 −0.64 0.58
  Recessive model 1129 / 1008 2.94 1.54–5.62 (≤0.001) 0 0.95 −0.52 0.60 −0.85 0.55
  Allelic model 1129 / 1008 1.30 1.10–1.54 (≤0.001) 31.2 0.22 0 1 −0.68 0.56
  CC vs. TT 1129 / 1008 3 1.56–5.76 (≤0.001) 0 0.87 −0.52 0.60 −1.20 0.44
  CT vs. TT 1129 / 1008 1.13 0.92–1.38 (0.24) 52.8 0.09 −0.68 0.49 −0.59 0.61
America Dominant model 1181 / 1278 1.26 1.05–1.51(≤0.001) 0 0.76 0.45 0.65 0.54 0.61
  Recessive model 1181 / 1278 1.16 0.88–1.52 (0.29) 0 0.89 2.55 0.01 6.60 0.06
  Allelic model 1181 / 1278 1.17 1.03–1.33 (0.01) 0 0.55 1.65 0.09 2.71 0.04
  CC vs. TT 1181 / 1278 1.26 0.93–1.71 (0.14) 0 0.84 2.25 0.02 3.17 0.05
  CT vs. TT 1181 / 1278 1.23 1.02–1.49 (0.03) 0 0.85 0.45 0.65 0.18 0.86
Ethnicity subgroups
Caucasian Dominant model 5881 / 7710 1.15 1.04–1.28 (0.008) 30.7 0.08 0.78 0.43 0.69 0.50
  Recessive model 5881 / 7710 1.17 1.06–1.30 (0.002) 6.7 0.3 1.98 0.04 2.44 0.02
  Allelic model 5881 / 7710 1.14 1.07–1.22 (≤0.001) 35.7 0.04 1.87 0.06 1.79 0.08
  CC vs. TT 5881 / 7710 1.23 1.01–1.49 (0.03) 4.6 0.4 1.14 0.25 0.72 0.48
  CT vs. TT 5881 / 7710 1.1 0.98–1.22 (0.09) 30.6 0.08 −0.68 0.49 −0.59 0.61
African-American Dominant model 706 / 698 1.14 0.89–1.45 (0.29) 0 0.76 0.45 0.65 0.54 0.61
  Recessive model 706 / 698 1.08 0.80–1.46 (0.6) 0 0.87 2.55 0.01 6.60 0.06
  Allelic model 706 / 698 1.08 0.93–1.27 (0.32) 0 0.74 1.65 0.09 2.71 0.04
  CC vs. TT 706 / 698 1.16 0.82–1.62 (0.4) 0 0.79 2.25 0.02 3.17 0.05
  CT vs. TT 706 / 698 1.13 0.87–1.45 (0.35) 0 0.8 0.45 0.65 0.18 0.86