Fig. 1
From: Novel MYO15A variants are associated with hearing loss in the two Iranian pedigrees
Pedigrees and the proband audiograms, as well as sequencing chromatograms. a Pedigree of family 1 having autosomal recessive form of NSHL disease is drawn. The proband (V: 4), for whom whole exome Sequencing has been carried out is indicated by arrow. b Audiogram for pure tone audiometry (PTA) of the proband (V: 4) with profound hearing loss in both ears. c Three-generation pedigree of family 2 having autosomal recessive form of NSHL disease is drawn. The proband (II: 3), for whom whole exome Sequencing has been carried out is indicated by arrow . d Audiogram for pure tone audiometry (PTA) of left and right ears of the affected proband (II: 3) showed profound hearing loss. Hearing impaired individuals are illustrated by black-filled symbols. e Partial sequence chromatograms of MYO15A gene from two unaffected (IV.2 and V.5) and affected individuals (V: 3 and V: 4) in family 1 illustrate T to A transition at position 6442. f Partial sequence chromatograms of MYO15A gene containing (c.10504dupT:p.C3502Lfs*15) variant in proband (II: 3), his father (I: 1) and his siblings (II: 2 and II:5) in family 2 illustrates insertion of T as indicated