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Table 3 Associations of the Top 20 SNPS with Persistent Cervical high-risk Infections

From: Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection

SNP Chr Base Position Near gene Reference allele MAF OR 95% CI P-value
5 10,847,898 DAPa C 6.87 3.41–13.84 7.15 × 10−8
rs143668247 1 199,701,882 NR5A2 C 0.35 3.66 2.24–5.97 2.03 × 10−7
rs200516199 17 29,917,727 MIR365–2 TTTGA 0.04 7.71 3.54–16.78 2.63 × 10− 7
rs116834259 20 42,742,258 JPH2 T 0.11 4.42 2.50–7.81 3.15 × 10− 7
rs11452236 20 42,751,590 JPH2 C 0.13 4.03 2.34–6.92 4.78 × 10− 7
rs74358070 20 42,727,587 JPH2 T 0.11 4.24 2.41–7.47 5.52 × 10−7
rs16832308 2 133,253,243 GPR390 A 0.04 6.30 3.05–13.01 6.49 × 10−7
rs62167448 2 133,254,091 GPR39 C 0.04 6.30 3.05–13.01 6.49 × 10−7
rs150410476 11 37,223,676 C11orf74 A 0.03 8.31 3.60–19.16 6.80 × 10−7
rs12740341 1 199,699,781 NR5A2 C 0.26 3.18 2.01–5.03 7.94 × 10−7
rs79032354 20 42,732,460 JPH2 C 0.13 3.91 2.27–6.71 7.96 × 10−7
rs6130527 20 42,733,946 JPH2 G 0.13 3.91 2.27–6.71 7.96 × 10−7
rs4810411 20 42,751,472 JPH2 C 0.13 3.81 2.24–6.50 7.99 × 10−7
rs2502139 1 199,695,633 NR5A2 A 0.27 3.17 2.00–5.02 8.94 × 10−7
rs34026413 1 199,695,074 NR5A2 A 0.27 3.10 1.97–4.88 7.94 × 10−6
1 26,304,144 PAFAH2a C 10.19 4.01–25.92 7.94 × 10− 6
rs543084794 2 133,250,145 GPR39a C 0.04 6.44 3.04–13.65 7.94 × 10− 6
rs79014529 20 42,717,781 TOX2 C 0.13 3.81 2.22–6.53 7.94 × 10− 6
rs1429702 1 199,694,059 NR5A2 T 0.27 3.10 1.96–4.87 7.94 × 10−6
rs6130520 20 42,716,399 TOX2 G 0.13 3.77 2.20–6.47 7.94 × 10−6
  1. For this analysis, 51 women with hrHPV infection at both the baseline and follow-up visits were compared to 355 women without hrHPV infections at either the baseline or follow-up visits. Base positions were based on hg19; aThe variant is not in 1000 genomes v1, the nearest gene was obtained from variants surrounding the base location on the specific chromosome; Odds Ratio (OR) and 95% Confidence Intervals (CI) were estimated using an additive genetic model; Models were adjusted for age, HIV status and the first principal components of the genotypes