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Table 2 Associations of the Top 20 SNPS with Prevalent Cervical high-risk Infections

From: Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection

SNP Chr Base Position Near gene Reference allele MAF OR 95% CI P-value
rs149473200 13 74,295,767 KLF12 G 0.03 7.06 3.19–15.63 1.43 × 10− 6
rs147344426 13 74,298,464 KLF12 G 0.03 7.06 3.19–15.63 1.43 × 10− 6
rs151071053 13 74,299,405 KLF12 T 0.03 7.06 3.19–15.63 1.43 × 10− 6
rs572823632 13 74,299,732 KLF12a GAA 0.03 7.06 3.19–15.63 1.43 × 10− 6
rs73010973 4 181,310,690 NCRNA00290 T 0.06 3.86 2.22–6.72 1.70 × 10− 6
rs73010975 4 181,310,704 NCRNA00290 T 0.06 3.86 2.22–6.72 1.70 × 10− 6
rs74739185 4 181,311,019 NCRNA00290 G 0.06 3.86 2.22–6.72 1.70 × 10− 6
rs79140020 4 181,311,020 NCRNA00290 T 0.06 3.86 2.22–6.72 1.70 × 10− 6
rs35833676 21 32,961,256 TIAM1 C 0.07 3.45 2.07–5.73 1.79 × 10− 6
rs3818252 20 58,675,675 C20orf197 C 0.57 2.22 1.60–3.10 2.06 × 10− 6
rs112893815 4 181,311,254 NCRNA00290 C 0.06 3.77 2.17–6.53 2.22 × 10− 6
8 74,725,256 UBE2Wa G 3.31 2.01–5.44 2.42 × 10− 6
rs506594 11 64,162,897 RPS6KA4 T 0.77 0.44 0.31–0.62 2.67 × 10− 6
rs73010952 4 181,308,382 NCRNA00290 G 0.06 3.69 2.14–6.38 2.77 × 10− 6
rs111800742 4 181,308,587 NCRNA00290 C 0.06 3.69 2.14–6.38 2.77 × 10− 6
rs73010957 4 181,309,080 NCRNA00290 A 0.06 3.69 2.14–6.38 2.77 × 10− 6
rs6574170 14 74,729,207 VSX2 A 0.04 5.29 2.63–10.67 3.16 × 10− 6
17 36,374,963 LOC440434a TA 0.48 0.35–0.65 3.17 × 10− 6
rs17090215 13 74,039,057 KLF12 C 0.05 3.90 2.20–6.92 3.21 × 10−6
rs375435036 1 72,615,562 NEGR1a C 0.15 2.52 1.71–3.73 3.49 × 10− 6
  1. For this analysis, 125 women with cervical hrHPV infections were compared to 392 women without cervical hrHPV infections at baseline. Base positions were based on hg19; aThe variant is not in 1000 genomes v1, the nearest gene was obtained from variants surrounding the base location on the specific chromosome; Odds Ratio (OR) and 95% Confidence Intervals (CI) were estimated using an additive genetic model; Models were adjusted for age, HIV status and the first principal components of the genotypes