The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis

Table 3 Summary of pooled effect sizes of ABCG2 and SLC2A9 polymorphisms on all outcomes^a

	Ethnicity	Gout				Hyperuricemia				Serum urate
	Ethnicity	Pooled OR₁	95% CI	Pooled OR₂	95% CI	Pooled OR₁	95% CI	Pooled OR₂	95% CI	Pooled MD₁	95% CI	Pooled MD₂	95% CI
*ABCG2*
rs2231142	Asian	4.53	4.10, 5.00	2.10	1.95, 2.26	2.25	1.80, 2.81	1.56	1.35, 1.80	18.41	8.68, 28.14	11.49	4.10, 18.89
rs2231142	Caucasian	3.24	2.39, 4.41	1.64	1.47, 1.82					50.43	32.66, 68.20	19.46	14.19, 24.73
rs72552713	Asian	3.86	2.30, 9.76	2.46	1.93, 3.18
rs2231137	Asian	0.43	0.34, 0.55	0.64	0.56, 0.72
*SLC2A9*
rs1014290	Asian	0.42	0.36, 0.49	0.65	0.58, 0.72					−21.47	−30.97, −11.96	−8.16	−16.63, 0.31
rs1014290	Caucasian	0.57	0.37, 0.87	0.75	0.63, 0.89					−32.33	−52.61,-12.05	−9.87	−25.27,5.54
rs3733591	Asian	1.55	1.17, 2.06	1.29	1.07, 1.55
rs3733591	Caucasian	1.03	0.60, 1.79	0.85	0.48, 1.50
rs6855911	Asian	0.61	0.20, 1.87	0.82	0.53, 1.27
rs6855911	Caucasian	0.36	0.28, 0.46	0.67	0.59, 0.77					−51.23	−57.22, −45.25	−20.65	−23.83, −17.47
rs6442295	Caucasian	0.38	0.29, 0.50	0.69	0.62, 0.78					−49.29	−59.85, −38.74	−20.43	−28.91, −11.94
rs7442295	Caucasian	0.35	0.28, 0.46	0.65	0.57, 0.74					−54.30	−58.78, −49.82	−18.34	−22.68, −13.99
rs12510549	Caucasian	0.44	0.34, 0.58	0.66	0.58, 0.76
rs16890979	Asian	NA^b		0.60	0.39, 0.94
rs734553	Caucasian									−29.29	−63.90, 5.33	−20.68	−47.08, 5.71

ABCG2 ATP-binding cassette sub-family G member 2, CI confidence interval, MD mean difference, NA not applicable, OR odds ratio, SLC2A9 solute carrier family 2 member 9
^aSignificant OR or MD in bold
^bUnable to pool OR₁ for rs16890979 due to no gout case with homozygous minor genotype found

ISSN: 1471-2350