Table 3 Relationships between the candidate SNPs and cervical cancer risk according to the stratification by age
SNP ID | Model | Genotype | > 43 years | ≤ 43 years | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR (95%CI) | p | Case | Control | OR (95%CI) | p | |||
PGF rs2268615 | Allele | C | 253 | 393 | 1.00 | 0.303 | 223 | 344 | 1.00 | 0.041 |
A | 99 | 131 | 1.17 (0.87–1.59) | 109 | 122 | 1.38 (1.01–1.88) | ||||
Genotype | CC | 89 | 147 | 1.00 | 71 | 126 | 1.00 | |||
CA | 75 | 99 | 1.25 (0.84–1.86) | 0.282 | 81 | 92 | 1.55 (1.02–2.36) | 0.039 | ||
AA | 12 | 16 | 1.22 (0.55–2.70) | 0.626 | 14 | 15 | 1.62 (0.74–3.56) | 0.228 | ||
Dominant | CC | 89 | 147 | 1.00 | 0.269 | 71 | 126 | 1.00 | 0.030 | |
CA-AA | 87 | 115 | 1.24 (0.85–1.82) | 95 | 107 | 1.56 (1.05–2.33) | ||||
Recessive | CC-CA | 164 | 246 | 1.00 | 0.795 | 152 | 218 | 1.00 | 0.481 | |
AA | 12 | 16 | 1.11 (0.51–2.41) | 14 | 15 | 1.31 (0.61–2.81) | ||||
Log-additive | – | – | – | 1.17 (0.86–1.60) | 0.317 | – | – | 1.40 (1.01–1.92) | 0.042 | |
TNFAIP2 rs710100 | Allele | G | 217 | 331 | 1.00 | 0.597 | 190 | 300 | 1.00 | 0.018 |
A | 135 | 191 | 1.08 (0.82–1.43) | 142 | 158 | 1.42 (1.06–1.90) | ||||
Genotype | GG | 64 | 111 | 1.00 | 54 | 99 | 1.00 | |||
GA | 89 | 109 | 1.41 (0.93–2.14) | 0.105 | 82 | 102 | 1.46 (0.94–2.27) | 0.092 | ||
AA | 23 | 41 | 0.96 (0.53–1.74) | 0.890 | 30 | 28 | 1.97 (1.07–3.63) | 0.031 | ||
Dominant | GG | 64 | 111 | 1.00 | 0.208 | 54 | 99 | 1.00 | 0.034 | |
GA-AA | 112 | 150 | 1.29 (0.87–1.91) | 112 | 130 | 1.57 (1.03–2.38) | ||||
Recessive | GG-GA | 153 | 220 | 1.00 | 0.418 | 136 | 201 | 1.00 | 0.103 | |
AA | 23 | 41 | 0.80 (0.46–1.38) | 30 | 28 | 1.59 (0.91–2.79) | ||||
Log-additive | – | – | – | 1.07 (0.81–1.41) | 0.635 | – | – | 1.42 (1.06–1.90) | 0.020 | |