Skip to main content

Table 7 Association between MIF polymorphisms and CDKN2A methylation in UC phenotype

From: Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis

rs755622 genotype adjusted OR (95% C.I.); p value
Chronic continuous GG GC CC GG vs. GC + CC
 Neither methylated (25) 17 6 2 reference
 Both methylated (12) 2 6 4 25.9 (2.55–262.6); p = 0.0059a
Relapse/remitting GG GC CC GG vs. GC + CC
 Neither methylated (52) 32 18 2 reference
 Both methylated (30) 15 15 0 1.93 (0.732–5.07); p = 0.18a
Total colitis GG GC CC GG vs. GC + CC
 Neither methylated (31) 21 10 0 reference
 Both methylated (21) 9 12 0 4.38 (1.12–17.2); p = 0.034b
Distal or left side colitis GG GC CC GG vs. GC + CC
 Neither methylated (46) 28 14 4 reference
 Both methylated (21) 8 9 4 2.75 (0.899–8.43); p = 0.076b
rs5844572 genotype adjusted OR (95% C.I.); p value
Chronic continuous X/X X/7 7/7 X/X vs. X/7 + 7/7
 Neither methylated (25) 15 8 2 reference
 Both methylated (12) 3 5 4 14.5 (1.46–144.3); p = 0.022a
Relapse/remitting X/X X/7 7/7 X/X vs. X/7 + 7/7
 Neither methylated (52) 38 14 0 reference
 Both methylated (30) 16 14 0 2.64 (0.970–7.17); p = 0.058a
Total colitis X/X X/7 7/7 X/X vs. X/7 + 7/7
 Neither methylated (31) 21 10 0 reference
 Both methylated (21) 10 11 0 3.47 (0.895–13.4); p = 0.072b
Distal or left side colitis X/X X/7 7/7 X/X vs. X/7 + 7/7
 Neither methylated (46) 32 12 2 reference
 Both methylated (21) 9 8 4 2.89 (0.931–8.98); p = 0.066b
  1. aadjusted for age, gender and disease extension
  2. badjusted for age, gender and clinical type
  3. X: 5 or 6 repeat allele; 7: 7 repeat allele
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us