Table 7 Association between MIF polymorphisms and CDKN2A methylation in UC phenotype

rs755622

adjusted OR (95% C.I.); p value

Chronic continuous

GG

GC

CC

GG vs. GC + CC

 Neither methylated (25)

17

6

2

reference

 Both methylated (12)

2

6

4

25.9 (2.55–262.6); p = 0.0059^a

Relapse/remitting

GG

GC

CC

GG vs. GC + CC

 Neither methylated (52)

32

18

2

reference

 Both methylated (30)

15

15

0

1.93 (0.732–5.07); p = 0.18^a

Total colitis

GG

GC

CC

GG vs. GC + CC

 Neither methylated (31)

21

10

0

reference

 Both methylated (21)

9

12

0

4.38 (1.12–17.2); p = 0.034^b

Distal or left side colitis

GG

GC

CC

GG vs. GC + CC

 Neither methylated (46)

28

14

4

reference

 Both methylated (21)

8

9

4

2.75 (0.899–8.43); p = 0.076^b

rs5844572

adjusted OR (95% C.I.); p value

Chronic continuous

X/X

X/7

7/7

X/X vs. X/7 + 7/7

 Neither methylated (25)

15

8

2

reference

 Both methylated (12)

3

5

4

14.5 (1.46–144.3); p = 0.022^a

Relapse/remitting

X/X

X/7

7/7

X/X vs. X/7 + 7/7

 Neither methylated (52)

38

14

0

reference

 Both methylated (30)

16

14

0

2.64 (0.970–7.17); p = 0.058^a

Total colitis

X/X

X/7

7/7

X/X vs. X/7 + 7/7

 Neither methylated (31)

21

10

0

reference

 Both methylated (21)

10

11

0

3.47 (0.895–13.4); p = 0.072^b

Distal or left side colitis

X/X

X/7

7/7

X/X vs. X/7 + 7/7

 Neither methylated (46)

32

12

2

reference

 Both methylated (21)

9

8

4

2.89 (0.931–8.98); p = 0.066^b