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Table 6 Association between MIF polymorphisms and CDKN2A methylation

From: Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis

rs755622 GG vs. GC + CC GG + GC vs. CC
adjusted OR* (95% CI); p value adjusted OR* (95% CI); p value
Neither methylated (77) reference reference
Both methylated (42) 2.70 (1.22–6.01); p = 0.015 3.92 (0.76–20.3); p = 0.10
rs5844572 X/X vs. X/7 + 7/7 X/X + X/7 vs. 7/7
adjusted OR* (95% C.I.); p value adjusted OR* (95% C.I.); p value
Neither methylated (77) reference reference
Both methylated (42) 2.87 (1.25–6.62); p = 0.013 12.0 (1.55–92.2); p = 0.017
  1. *by logistic regression analysis after adjustment for age, gender, clinical type and disease extension
  2. X: 5 or 6 repeat allele; 7: 7 repeat allele
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BMC Medical Genetics

ISSN: 1471-2350

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