| |
Overall UC
|
p14-UM
|
p14-M
|
pa
|
p16-UM
|
p16-M
|
pb
|
|---|
|
Number of sample
|
159
|
105
|
54
| |
89
|
70
| |
|
Mean age ± SD
|
41.3 ± 13.6
|
40.4 ± 13.4
|
43.0 ± 14.0
|
NS
|
42.1 ± 15.2
|
40.2 ± 11.3
|
NS
|
|
Male: female
|
91: 68
|
66: 39
|
25: 29
|
NS
|
50: 39
|
41: 29
|
NS
|
|
Clinical type
| | | |
NS
| | |
NS
|
|
Chronic continuous
|
56
|
38
|
18
| |
31
|
25
| |
|
Relapse/remitting
|
103
|
67
|
36
| |
58
|
45
| |
|
Disease extension
| | | |
NS
| | |
NS
|
|
Total colitis
|
74
|
49
|
25
| |
35
|
39
| |
|
Distal or left side colitis (rs755622 G > C)
|
85
|
56
|
29
| |
54
|
31
| |
|
GG
|
93
|
68
|
25
|
0.010
|
57
|
36
|
NS
|
|
GC
|
57
|
32
|
25
| |
28
|
29
| |
|
CC
|
9
|
5
|
4
|
NS
|
4
|
5
|
NS
|
|
C allele freqency (rs5844572 CATT repeat)
|
23.6%
|
20.0%
|
30.6%
|
0.050
|
20.2%
|
27.9%
|
NS
|
|
5/5
|
16
|
13
|
3
| |
9
|
7
| |
|
5/6
|
57
|
40
|
17
| |
31
|
26
| |
|
5/7
|
28
|
16
|
12
| |
12
|
16
| |
|
6/6
|
28
|
19
|
9
| |
23
|
5
| |
|
6/7
|
23
|
14
|
9
| |
12
|
11
| |
|
7/7
|
7
|
3
|
4
| |
2
|
5
| |
|
5 repeat freqency
|
36.8%
|
39.0%
|
32.4%
| |
34.3%
|
40.0%
| |
|
6 repeat freqency
|
42.8%
|
43.8%
|
40.7%
| |
50.0%
|
42.1%
| |
|
7 repeat freqency
|
20.4%
|
17.1%
|
26.9%
|
NS
|
15.7%
|
26.4%
|
0.036
|
- p14-UM, p14ARF unmethylated; p14-M, p14ARF methylated; p16-UM, p16INK4a unmethylated;
- p16-M, p16INK4a methylated; ap14-UM vs. p14-M; bp16-UM vs. p16-M; NS Not significant
