Table 2 The association of genotype and allele of IL-6 rs12700386 polymorphism with osteoarthritis risk
Genotype | Genotypes and alleles | Frequencies N(%) | OR (95% CI) | P | |
|---|---|---|---|---|---|
Cases (n = 351) | Controls (n = 409) | ||||
rs12700386 | |||||
Co-dominant | GG | 193 (55.0%) | 259 (63.3%) | 1.00(reference) | |
Heterozygote | GC | 134 (38.2%) | 134 (32.8%) | 1.34 (0.99,1.82) | 0.063 |
Homozygote | CC | 24 (6.8%) | 16 (3.9%) | 2.01 (1.04–3.89) | 0.045 |
Dominant | GG | 193 (55.0%) | 259 (63.3%) | 1.00(reference) | |
GC + CC | 158 (45.0%) | 150 (36.7%) | 1.41 (1.06–1.89) | 0.022 | |
Recessive | GC + GG | 327 (93.2%) | 393 (96.1%) | 1.00(reference) | |
CC | 24 (6.8%) | 16 (3.9%) | 1.80 (0.94–3.45) | 0.075 | |
Allele | G | 520 (74.1%) | 652 (79.7%) | 1.00(reference) | |
C | 182 (25.9%) | 166 (20.3%) | 1.38 (1.08–1.75) | 0.010 | |