Table 3 Genotypic distribution of the investigated variants for patients with GC in comparison to control group. P-value, OR and 95%CI were obtained with logistic regression adjusted for age, which was done for the genotype as reference in each line (DEL/DEL vs. the other genotypes of that marker, and the same for INS/DEL and INS/INS)
From: Investigation of INDEL variants in apoptosis: the relevance to gastric cancer
Gene | Genotype | Case (%)* | Control (%)* | P-value | OR (95%CI) |
|---|---|---|---|---|---|
BCL2 | rs11269260 | 93 | 98 | ||
DEL/DEL | 13 (14) | 19 (19.4) | 0.844 | 1.090 (0.463–2.567) | |
INS/DEL | 51 (54.8) | 42 (42.9) | 0.149 | 1.589 (0.848–2.977) | |
INS/INS | 29 (31.2) | 37 (37.8) | 0.092 | 0.556 (0.281–1.101) | |
CASP3 | rs4647655 | 93 | 96 | ||
DEL/DEL | 47 (50.5) | 48 (50.0) | 0.898 | 0.959 (0.511–1.802) | |
INS/DEL | 39 (41.9) | 39 (40.6) | 0.995 | 1.002 (0.528–1.904) | |
INS/INS | 7 (7.5) | 9 (9.4) | 0.825 | 1.136 (0.365–3.537) | |
CASP8 | rs3834129 | 93 | 98 | ||
DEL/DEL | 27 (29.0) | 19 (19.4) | 0.098 | 1.851 (0.893–3.835) | |
INS/DEL | 38 (40.9) | 42 (42.9) | 0.987 | 0.995 (0.526–1.880) | |
INS/INS | 28 (30.1) | 37 (37.7) | 0.132 | 0.596 (0.303–1.169) | |
rs59308963 | 89 | 93 | |||
DEL/DEL | 30 (33.7) | 29 (31.2) | 0.749 | 1.116 (0.568–2.195) | |
INS/DEL | 41 (46.1) | 44 (47.3) | 0.727 | 0.893 (0.471–1.690) | |
INS/INS | 18 (20.2) | 20 (21.5) | 0.953 | 1.024 (0.467–2.244) | |
CASP9 | rs4645982 | 81 | 58 | ||
DEL/DEL | 16 (19.8) | 13 (22.4) | 0.897 | 0.943 (0.392–2.272) | |
INS/DEL | 24 (29.6) | 20 (34.5) | 0.583 | 0.808 (0.377–1.732) | |
INS/INS | 41 (50.6) | 25 (43.1) | 0.535 | 1.254 (0.613–2.567) | |
rs61079693 | 89 | 94 | |||
DEL/DEL | 22 (24.7) | 26 (27.7) | 0.418 | 0.742 (0.360–1.529) | |
INS/DEL | 46 (51.7) | 44 (46.8) | 0.765 | 1.102 (0.585–2.076) | |
INS/INS | 21 (23.6) | 24 (25.5) | 0.621 | 1.209 (0.570–2.563) | |
FADD | rs4197 | 93 | 97 | ||
DEL/DEL | 31 (33.3) | 41 (42.3) | 0.099 | 0.573 (0.295–1.111) | |
INS/DEL | 57 (61.3) | 48 (49.5) | 0.046 | 1.940 (1.011–3.725) | |
INS/INS | 5 (5.4) | 8 (8.2) | 0.441 | 0.600 (0.163–2.202) | |
FAS | rs10562972 | 89 | 93 | ||
DEL/DEL | 1 (1.1) | 0 (0.0) | 0.988 | 991,452.554 (0.000–∞) | |
INS/DEL | 10 (11.2) | 21 (22.6) | 0.260 | 0.603 (0.250–1.454) | |
INS/INS | 78 (87.6) | 72 (77.4) | 0.329 | 1.535 (0.650–1.125) | |
TP53 | rs17880560 | 87 | 93 | ||
DEL/DEL | 57 (65.5) | 58 (62.4) | 0.738 | 1.119 (0.579–2.166) | |
INS/DEL | 26 (29.9) | 31 (33.3) | 0.714 | 0.880 (0.445–1.741) | |
INS/INS | 4 (4.6) | 4 (4.3) | 0.964 | 1.035 (0.232–4.623) |