Table 2 Distribution of TP53 p.Arg72Pro polymorphism according to the different genetic models
From: p.Arg72Pro polymorphism of P53 and breast cancer risk: a meta-analysis of case-control studies
| Â | Â | Sample size | Genetic | Pooled | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
Group | N | Cases/Controls | Models | OR (95% CI) | P-value | I2 | Phet |
Overall | 21 | 7841/8876 | Â | Â | Â | Â | Â |
|  |  |  | Dominant | 1.09 (1.02–1.16) FE | 0.01 | 31% | 0.09 |
|  |  |  | Recessive | 1.07 (0.97–1.18) FE | 0.19 | 36% | 0.05 |
|  |  |  | Additive | 1.09 (1.01–1.17) FE | 0.03 | 47% | 0.01 |
Caucasian | 11 | 5472/6396 | Â | Â | Â | Â | Â |
|  |  |  | Dominant | 1.09 (1.01–1.17) FE | 0.02 | 27% | 0.19 |
|  |  |  | Recessive | 1.09 (0.95–1.25) FE | 0.22 | 10% | 0.34 |
|  |  |  | Additive | 1.07 (1.01–1.14) FE | 0.02 | 39% | 0.09 |
Asian | 9 | 2244/2354 | Â | Â | Â | Â | Â |
|  |  |  | Dominant | 1.06 (0.94–1.20) FE | 0.33 | 45% | 0.07 |
|  |  |  | Recessive | 1.01 (0.87–1.17) FE | 0.88 | 48% | 0.05 |
|  |  |  | Additive | 1.06 (0.91–1.23) RE | 0.46 | 54% | 0.03 |
African | 1 | 125/126 | Â | Â | Â | Â | Â |
|  |  |  | Dominant | 1.36 (0.83–2.23) | 0.23 |  |  |
|  |  |  | Recessive | 2.14 (1.08–4.23) | 0.03 | – | – |
|  |  |  | Additive | 1.49 (1.03–2.16) | 0.03 | – | – |