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Table 7 Cox proportional hazard regression analysis evaluating risk of cardiovascular mortality regarding rs1478604 of TSP-1 in the study population divided in the total population, and into the two genders

From: Increased cardiovascular mortality in females with the a/a genotype of the SNPs rs1478604 and rs2228262 of thrombospondin-1

Variable

 

Total population

  

Females

  

Males

 

HR

95%CI

p-value

HR

95%CI

p-value

HR

95%CI

p-value

Age

1.17

1.10–1.25

< 0.0001

1.20

1.07–1.34

0.002

1.20

1.10–1.30

< 0.0001

IHD

1.23

0.74–2.03

0.42

1.13

0.44–2.89

0.80

1.05

0.55–2.01

0.88

Hypertension

1.17

0.71–1.93

0.53

1.85

0.72–4.71

0.20

1.04

0.58–1.89

0.89

Diabetes

1.25

0.82–1.93

0.30

1.90

0.86–4.18

0.11

0.87

0.50–1.50

0.61

AECI/ARB

1.00

0.62–1.61

0.99

0.73

0.32–1.66

0.45

1.30

0.72–2.36

0.39

Beta blockers

0.77

0.48–1.24

0.28

0.76

0.35–1.65

0.48

0.78

0.42–1.46

0.43

Atrial fibr.

2.23

1.30–3.86

0.004

4.66

1.69–12.83

0.003

1.71

0.85–3.45

0.13

Hb < 120 g/L

1.42

0.82–2.49

0.21

2.52

1.07–5.94

0.04

1.03

0.44–2.40

0.94

EF < 40%

1.79

0.96–3.33

0.07

3.57

1.14–11.20

0.03

1.41

0.63–3.16

0.40

TSP-1 rs1478604, T/T

1.62

1.03–2.53

0.04

3.18

1.35–7.50

0.008

1.18

0.68–2.05

0.56

  1. ACEI angiotensin convering enzyme inhibitors, ARB angiotensin receptor inhibitors, EF ejection fraction, HR hazard ratio