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Table 6 Cox proportional hazard regression analysis evaluating risk of cardiovascular mortality in the study population divided in the total population, and into the two genders regarding rs2228262 of TSP-1

From: Increased cardiovascular mortality in females with the a/a genotype of the SNPs rs1478604 and rs2228262 of thrombospondin-1

Variable   Total population    Females    Males  
HR 95%CI p-value HR 95%CI p-value HR 95%CI p-value
Age 1.18 1.11–1.26 < 0.0001 1.17 1.05–1.31 0.005 1.22 1.12–1.32 < 0.0001
IHD 1.33 0.79–2.24 0.29 1.85 0.70–4.88 0.21 0.93 0.48–1.82 0.84
Hypertension 1.26 0.74–2.16 0.40 2.10 0.75–5.86 0.16 1.23 0.66–2.29 0.52
Diabetes 1.21 0.76–1.92 0.41 2.06 0.90–4.73 0.09 0.84 0.48–1.48 0.55
AECI/ARB 1.03 0.63–1.70 0.91 0.65 0.26–1.63 0.36 1.29 0.70–2.38 0.41
Beta blockers 0.75 0.46–1.24 0.26 0.61 0.27–1.42 0.25 0.73 0.38–1.39 0.33
Atrial fibr. 2.02 1.11–3.66 0.02 4.72 1.60–13.92 0.005 1.83 0.91–3.67 0.09
Hb < 120 g/L 1.55 0.86–2.79 0.14 3.70 1.52–9.00 0.004 1.10 0.48–2.54 0.82
EF < 40% 1.77 0.93–3.37 0.08 3.12 0.82–11.85 0.09 1.62 0.72–3.66 0.24
TSP-1 rs2228262, A/A 1.48 0.80–2.75 0.21 7.12 1.11–45.78 0.04 1.14 0.59–2.23 0.69
  1. ACEI angiotensin convering enzyme inhibitors, ARB angiotensin receptor inhibitors, EF ejection fraction, HR hazard ratio