|
Kinds
|
SNPs
|
Regions
|
Group
|
Value (mean ± SD)
|
β
|
P value
|
|---|
|
MM
|
Mm
|
mm
|
|---|
|
(mean ± SD)
|
N
|
(mean ± SD)
|
N
|
(mean ± SD)
|
N
|
|---|
|
AV45-PET
|
rs10494884
|
temporal
|
AD
|
1.387 ± 0.2783
|
17
|
1.415 ± 0.3144
|
17
|
1.566 ± 0.2483
|
12
|
0.06873
|
0.119
|
| | |
temporal
|
NC
|
1.201 ± 0.2014
|
44
|
1.219 ± 0.2556
|
85
|
1.333 ± 0.2917
|
24
|
0.05121
|
0.08755
|
| | |
frontal
|
AD
|
1.489 ± 0.2873
|
17
|
1.501 ± 0.3219
|
17
|
1.701 ± 0.2474
|
12
|
0.08014
|
0.08302
|
| | |
frontal
|
NC
|
1.259 ± 0.2147
|
44
|
1.295 ± 0.2868
|
85
|
1.392 ± 0.2961
|
24
|
0.04313
|
0.1718
|
| | |
SUVR
|
AD
|
1.33 ± 0.2193
|
17
|
1.332 ± 0.2515
|
17
|
1.494 ± 0.17
|
12
|
0.06683
|
0.06938
|
| | |
SUVR
|
NC
|
1.103 ± 0.1775
|
44
|
1.125 ± 0.2015
|
85
|
1.201 ± 0.2176
|
24
|
0.03969
|
0.09432
|
| |
rs11118322
|
temporal
|
AD
|
1.387 ± 0.2783
|
17
|
1.415 ± 0.3144
|
17
|
1.566 ± 0.2483
|
12
|
0.06873
|
0.119
|
| | |
temporal
|
NC
|
1.201 ± 0.2014
|
44
|
1.219 ± 0.2556
|
85
|
1.333 ± 0.2917
|
24
|
0.05121
|
0.08755
|
| | |
frontal
|
AD
|
1.489 ± 0.2873
|
17
|
1.501 ± 0.3219
|
17
|
1.701 ± 0.2474
|
12
|
0.08014
|
0.08302
|
| | |
frontal
|
NC
|
1.259 ± 0.2147
|
44
|
1.295 ± 0.2868
|
85
|
1.392 ± 0.2961
|
24
|
0.04313
|
0.1718
|
| |
rs1323721
|
temporal
|
AD
|
1.387 ± 0.2783
|
17
|
1.415 ± 0.3144
|
17
|
1.566 ± 0.2483
|
12
|
0.06873
|
0.119
|
| | |
temporal
|
NC
|
1.2 ± 0.2035
|
43
|
1.219 ± 0.2541
|
86
|
1.333 ± 0.2917
|
24
|
0.05124
|
0.08938
|
| | |
frontal
|
AD
|
1.489 ± 0.2873
|
17
|
1.501 ± .3219
|
17
|
1.701 ± 0.2474
|
12
|
0.08014
|
0.08302
|
| | |
frontal
|
NC
|
1.257 ± 0.2169
|
43
|
1.295 ± 0.2851
|
86
|
1.392 ± 0.2961
|
24
|
0.04191
|
0.1878
|
| |
rs17259045
|
frontal
|
AD
|
1.593 ± 0.2906
|
37
|
1.37 ± 0.2805
|
9
|
0
|
0
|
−0.1974
|
0.02681
|
| | |
frontal
|
NC
|
1.312 ± 0.2783
|
120
|
1.24 ± 0.2391
|
30
|
1.358 ± 0.3367
|
2
|
−0.04546
|
0.3264
|
| | |
temporal
|
AD
|
1.486 ± 0.2857
|
37
|
1.273 ± 0.2458
|
9
|
0
|
0
|
−0.1864
|
0.02785
|
| | |
temporal
|
NC
|
1.242 ± 0.2563
|
120
|
1.186 ± 0.2276
|
30
|
1.168 ± 0.2109
|
2
|
−0.05859
|
0.1847
|
| | |
SUVR
|
AD
|
1.413 ± 0.2178
|
37
|
1.214 ± 0.2062
|
9
|
0
|
0
|
−0.1775
|
0.01173
|
| | |
SUVR
|
NC
|
1.14 ± 0.2074
|
120
|
1.085 ± 0.1543
|
30
|
1.169 ± 0.2835
|
2
|
−0.04196
|
0.2297
|
| | |
cingulate
|
AD
|
1.711 ± 0.3232
|
37
|
1.455 ± 0.2704
|
9
|
0
|
0
|
−0.2262
|
0.02717
|
| | |
cingulate
|
NC
|
1.431 ± 0.3073
|
120
|
1.351 ± 0.2576
|
30
|
1.482 ± 0.2336
|
2
|
−0.06105
|
0.2494
|
| | |
parietal
|
AD
|
1.604 ± 0.2992
|
37
|
1.369 ± 0.2273
|
9
|
0
|
0
|
−0.2085
|
0.01895
|
| | |
parietal
|
NC
|
1.33 ± 0.29
|
120
|
1.251 ± 0.2344
|
30
|
1.341 ± 0.353
|
2
|
−0.06408
|
0.1983
|
| |
rs41308433
|
temporal
|
AD
|
1.5 ± 0.3029
|
30
|
1.33 ± 0.2385
|
15
|
1.498 ± 0
|
1
|
−0.08598
|
0.1943
|
| | | |
NC
|
1.252 ± 0.2708
|
105
|
1.188 ± 0.1949
|
45
|
1.151 ± 0.1519
|
3
|
−0.05517
|
0.1494
|
|
CSF Aβ42
|
rs12567945
|
CSF Aβ42
|
AD
|
139.6 ± 41.82
|
34
|
140.3 ± 34.01
|
5
|
233.9 ± 0
|
1
|
14.13
|
0.3726
|
| | | |
NC
|
191.6 ± 53.29
|
116
|
219.7 ± 45.29
|
16
|
0
|
0
|
28.66
|
0.02589
|
- AD alzheimer’s disease, NC normal controls, SNPs single nucleotide polymorphisms, SD standard deviations, SUVR standardized uptake values ratios
