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Table 3 Stratified of positive results in AD group and NC group

From: Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer’s disease

Kinds

SNPs

Regions

Group

Value (mean ± SD)

β

P value

MM

Mm

mm

(mean ± SD)

N

(mean ± SD)

N

(mean ± SD)

N

AV45-PET

rs10494884

temporal

AD

1.387 ± 0.2783

17

1.415 ± 0.3144

17

1.566 ± 0.2483

12

0.06873

0.119

  

temporal

NC

1.201 ± 0.2014

44

1.219 ± 0.2556

85

1.333 ± 0.2917

24

0.05121

0.08755

  

frontal

AD

1.489 ± 0.2873

17

1.501 ± 0.3219

17

1.701 ± 0.2474

12

0.08014

0.08302

  

frontal

NC

1.259 ± 0.2147

44

1.295 ± 0.2868

85

1.392 ± 0.2961

24

0.04313

0.1718

  

SUVR

AD

1.33 ± 0.2193

17

1.332 ± 0.2515

17

1.494 ± 0.17

12

0.06683

0.06938

  

SUVR

NC

1.103 ± 0.1775

44

1.125 ± 0.2015

85

1.201 ± 0.2176

24

0.03969

0.09432

 

rs11118322

temporal

AD

1.387 ± 0.2783

17

1.415 ± 0.3144

17

1.566 ± 0.2483

12

0.06873

0.119

  

temporal

NC

1.201 ± 0.2014

44

1.219 ± 0.2556

85

1.333 ± 0.2917

24

0.05121

0.08755

  

frontal

AD

1.489 ± 0.2873

17

1.501 ± 0.3219

17

1.701 ± 0.2474

12

0.08014

0.08302

  

frontal

NC

1.259 ± 0.2147

44

1.295 ± 0.2868

85

1.392 ± 0.2961

24

0.04313

0.1718

 

rs1323721

temporal

AD

1.387 ± 0.2783

17

1.415 ± 0.3144

17

1.566 ± 0.2483

12

0.06873

0.119

  

temporal

NC

1.2 ± 0.2035

43

1.219 ± 0.2541

86

1.333 ± 0.2917

24

0.05124

0.08938

  

frontal

AD

1.489 ± 0.2873

17

1.501 ± .3219

17

1.701 ± 0.2474

12

0.08014

0.08302

  

frontal

NC

1.257 ± 0.2169

43

1.295 ± 0.2851

86

1.392 ± 0.2961

24

0.04191

0.1878

 

rs17259045

frontal

AD

1.593 ± 0.2906

37

1.37 ± 0.2805

9

0

0

−0.1974

0.02681

  

frontal

NC

1.312 ± 0.2783

120

1.24 ± 0.2391

30

1.358 ± 0.3367

2

−0.04546

0.3264

  

temporal

AD

1.486 ± 0.2857

37

1.273 ± 0.2458

9

0

0

−0.1864

0.02785

  

temporal

NC

1.242 ± 0.2563

120

1.186 ± 0.2276

30

1.168 ± 0.2109

2

−0.05859

0.1847

  

SUVR

AD

1.413 ± 0.2178

37

1.214 ± 0.2062

9

0

0

−0.1775

0.01173

  

SUVR

NC

1.14 ± 0.2074

120

1.085 ± 0.1543

30

1.169 ± 0.2835

2

−0.04196

0.2297

  

cingulate

AD

1.711 ± 0.3232

37

1.455 ± 0.2704

9

0

0

−0.2262

0.02717

  

cingulate

NC

1.431 ± 0.3073

120

1.351 ± 0.2576

30

1.482 ± 0.2336

2

−0.06105

0.2494

  

parietal

AD

1.604 ± 0.2992

37

1.369 ± 0.2273

9

0

0

−0.2085

0.01895

  

parietal

NC

1.33 ± 0.29

120

1.251 ± 0.2344

30

1.341 ± 0.353

2

−0.06408

0.1983

 

rs41308433

temporal

AD

1.5 ± 0.3029

30

1.33 ± 0.2385

15

1.498 ± 0

1

−0.08598

0.1943

   

NC

1.252 ± 0.2708

105

1.188 ± 0.1949

45

1.151 ± 0.1519

3

−0.05517

0.1494

CSF Aβ42

rs12567945

CSF Aβ42

AD

139.6 ± 41.82

34

140.3 ± 34.01

5

233.9 ± 0

1

14.13

0.3726

   

NC

191.6 ± 53.29

116

219.7 ± 45.29

16

0

0

28.66

0.02589

  1. AD alzheimer’s disease, NC normal controls, SNPs single nucleotide polymorphisms, SD standard deviations, SUVR standardized uptake values ratios
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BMC Medical Genetics

ISSN: 1471-2350

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