Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer’s disease

BMC Medical Genetics

Table 2 The association of genetic variants in CR1 gene with Aβ deposition on AV-45 PET among all people

SNPs	Gene regions	Position (Chromosome)	Major allele	Minor allele	Regions	β	P value
rs10494884	intron variant	1:207674531	G	A	temporal	0.03364	0.03392
					frontal	0.03543	0.03845
					SUVR	0.02647	0.04447
rs11118322	intron variant	1:207674706	T	C	temporal	0.03342	0.03448
rs11118322	intron variant	1:207674706	T	C	frontal	0.03477	0.04155
rs1323721	intron variant	1:207649895	A	G	temporal	0.03245	0.04141
rs1323721	intron variant	1:207649895	A	G	frontal	0.03381	0.04894
rs17259045	missense	1:207609362	A	G	frontal	−0.0773	0.007581
					temporal	−0.06968	0.009251
					SUVR	−0.05298	0.01725
					cingulate	−0.07068	0.02512
					parietal	−0.06473	0.03033
rs41308433	intron variant	1:207699490	A	C	temporal	−0.0427	0.04292

CR1 complement component (3b/4b) receptor 1 gene, SNPs single nucleotide polymorphisms, Aβ amyloid protein, SUVR standardized uptake values ratios

ISSN: 1471-2350