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Table 2 Association of coronary artery disease genetic risk score with coronary artery calcification in the Heinz Nixdorf Recall study

From: Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study

 

Mean GRS

OR [95% CI], p

Low

Intermediate

OR [95% CI], p

High

OR [95% CI], p

All

 N

4041

809

2424

808

 Model 1

1.18 [1.10; 1.27], 6.37 × 10−6

Ref.

1.29 [1.07; 1.55], 0.007

1.57 [1.25; 1.96], 9.7 × 10−5

 N

3748

752

2257

739

 Model 2

1.19 [1.10; 1.29], 1.30 × 10−5

 

1.35 [1.10; 1.64], 0.004

1.62 [1.26; 2.07], 0.0002

Men

 N

1919

392

1141

386

 Model 1

1.28 [1.13; 1.44], 5.60 × 10−5

Ref.

1.67 [1.25; 2.23], 0.0005

2.17 [1.48; 3.17], 7.0 × 10− 5

 N

1765

366

1052

347

 Model 2

1.29 [1.13; 1.47], 0.0001

 

1.90 [1.39; 2.60], 6.4 × 10−5

2.37 [1.56; 3.60], 4.9 × 10− 5

Women

 N

2122

417

1283

422

 Model 1

1.13 [1.03; 1.23], 0.009

Ref.

1.09 [0.87; 1.38], 0.45

1.30 [0.99; 1.73], 0.06

 N

1983

386

1205

392

 Model 2

1.13 [1.03; 1.24], 0.01

Ref.

1.07 [0.83; 1.38], 0.59

1.28 [0.94; 1.76], 0.12

  1. N: total number of participants in the analyses. OR odds ratio, [95%CI] 95%confidence interval, Ref reference. Model 1 is adjusted for age and sex. Model 2 is adjusted for age, sex, diabetes, body mass index, systolic blood pressure, smoking, antihypertensive medication, lipid lowering medication, low density lipoprotein-cholesterol and high density lipoprotein-cholesterol