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Table 2 Association of coronary artery disease genetic risk score with coronary artery calcification in the Heinz Nixdorf Recall study

From: Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study

  Mean GRS
OR [95% CI], p
Low Intermediate
OR [95% CI], p
High
OR [95% CI], p
All
 N 4041 809 2424 808
 Model 1 1.18 [1.10; 1.27], 6.37 × 10−6 Ref. 1.29 [1.07; 1.55], 0.007 1.57 [1.25; 1.96], 9.7 × 10−5
 N 3748 752 2257 739
 Model 2 1.19 [1.10; 1.29], 1.30 × 10−5   1.35 [1.10; 1.64], 0.004 1.62 [1.26; 2.07], 0.0002
Men
 N 1919 392 1141 386
 Model 1 1.28 [1.13; 1.44], 5.60 × 10−5 Ref. 1.67 [1.25; 2.23], 0.0005 2.17 [1.48; 3.17], 7.0 × 10− 5
 N 1765 366 1052 347
 Model 2 1.29 [1.13; 1.47], 0.0001   1.90 [1.39; 2.60], 6.4 × 10−5 2.37 [1.56; 3.60], 4.9 × 10− 5
Women
 N 2122 417 1283 422
 Model 1 1.13 [1.03; 1.23], 0.009 Ref. 1.09 [0.87; 1.38], 0.45 1.30 [0.99; 1.73], 0.06
 N 1983 386 1205 392
 Model 2 1.13 [1.03; 1.24], 0.01 Ref. 1.07 [0.83; 1.38], 0.59 1.28 [0.94; 1.76], 0.12
  1. N: total number of participants in the analyses. OR odds ratio, [95%CI] 95%confidence interval, Ref reference. Model 1 is adjusted for age and sex. Model 2 is adjusted for age, sex, diabetes, body mass index, systolic blood pressure, smoking, antihypertensive medication, lipid lowering medication, low density lipoprotein-cholesterol and high density lipoprotein-cholesterol