Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study

BMC Medical Genetics

Table 1 Characteristics of the Heinz Nixdorf Recall study population

	All Events/N 343/4041	Events N (%) 343 (8.5)	No Events N (%) 3693 (91.5)	p^c
Age (years) ^a	58.9 ± 7.6	63.5 ± 7.8	58.9 ± 7.6	< 0.0001
Men	1919 (47.5)	219 (63.9)	1700 (46.0)	< 0.0001
BMI (kg/m²)	27.7 ± 4.6	28.7 ± 4.2	27.72 ± 4.6	< 0.0001
Smoker	2291 (56.7)	211 (61.5)	2080 (56.3)	0.06
Diabetes	490 (12.1)	78 (22.7)	412 (11.1)	< 0.0001
Systolic blood pressure (mmHg)	131.8 ± 20.2	142.5 ± 23.6	131.8 ± 20.2	< 0.0001
Diastolic blood pressure (mmHg)	81.3 ± 10.7	83.8 ± 12.3	81.3 ± 10.7	0.0004
Use of antihypertensive medication	1263 (31.3)	163 (47.5)	1100 (29.8)	< 0.0001
log(CAC + 1) ^b	2.3 (0; 4.5)	4.8 (2.7; 6.1)	2.3 (0; 4.5)	< 0.0001
CAC > 0	2734 (67.7)	298 (86.9)	2436 (65.9)	< 0.0001
Use of lipid lowering medication	360 (9.5)	39 (12.2)	321 (9.3)	0.11
LDL-cholesterol (mg/dL)	146.8 ± 36.3	147.9 ± 34.7	146.8 ± 36.3	0.40
HDL-cholesterol (mg/dL)	59.4 ± 17.1	55.2 ± 16.8	59.4 ± 17.1	< 0.0001
Triglycerides (mg/dL) ^b	123.0 (89.0; 177.0)	141.0 (101.0; 203.0)	121.0 (88.0; 175.0)	< 0.0001
Total cholesterol ^a	231.4 ± 38.7	232.2 ± 39.5	231.3 ± 38.6	0.73
Coronary artery disease GRS ^a	0.03 ± 0.003	0.04 ± 0.003	0.03 ± 0.003	0.006

LDL low density lipoprotein, HDL high density lipoprotein, CAC coronary artery calcification, GRS genetic risk score. Data are given as number (percentage) unless otherwise indicated
^a Data are given as mean ± SD. ^b Data are given as median (Q1; Q3)
^cp are for differences between CHD stratified groups using χ2 or Fisher exact test, t test or Mann-Whitney U test

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