Genetic polymorphisms of PIP5K2A and course of schizophrenia

BMC Medical Genetics

Table 3 Association of PIP5K2A haplotypes with course of schizophrenia

SNPs	Haplotype	Frequency	Group 1, Group 2 frequencies	Chi square	P_asym	P_Perm
rs736203/rs943190	TT	0.571	0.565, 0.585	0.269	0.6043	0.9971
	CC	0.342	0.332, 0.366	0.836	0.3606	0.9437
	TC	0.046	0.053, 0.031	1.715	0.1904	0.7448
	CT	0.040	0.050, 0.018	4.463	0.0346	0.2097
rs10430590/rs1132816	AA	0.570	0.557, 0.608	1.397	0.2372	0.5328
	TA	0.211	0.211, 0.212	0.001	0.9750	1.0
	AG	0.127	0.128, 0.126	0.005	0.9451	0.9998
	TG	0.091	0.104, 0.054	3.990	0.0458	0.1130
rs943190/rs1132816	TA	0.497	0.501, 0.487	0.108	0.7430	0.9812
	CA	0.285	0.268, 0.334	2.827	0.0927	0.2276
	TG	0.117	0.117, 0.119	0.008	0.9309	0.9998
	CG	0.101	0.115, 0.061	4.276	0.0386	0.0946
rs11013052/rs1132816	CA	0.643	0.632, 0.675	1.075	0.2998	0.6804
	AA	0.139	0.137, 0.145	0.079	0.7791	0.9898
	AG	0.114	0.129, 0.073	4.119	0.0424	0.1423
	CG	0.104	0.103, 0.107	0.029	0.8652	0.9973
rs1132816/rs943194	AG	0.606	0.595, 0.637	1.004	0.3163	0.9144
	AC	0.175	0.173, 0.183	0.099	0.7535	0.9998
	GC	0.175	0.175, 0.103	5.158	0.0231	0.1419
	GG	0.063	0.058, 0.077	0.786	0.3754	0.9502

P_asym - asymptotic P value, P_Perm - empirical P value for 10,000 permutations. Group 1 – group of patients with continuous course of schizophrenia (n = 269), Group 2 – group of patients with episodic course of schizophrenia (n = 115). Bold text indicates p-value< 0.05

ISSN: 1471-2350