Genetic polymorphisms of PIP5K2A and course of schizophrenia

Poltavskaya, Evgeniya G.; Fedorenko, Olga Yu.; Vyalova, Natalya M.; Kornetova, Elena G.; Bokhan, Nikolay A.; Loonen, Anton J. M.; Ivanova, Svetlana A.

doi:10.1186/s12881-020-01107-w

BMC Medical Genetics

Table 2 Frequency distribution of genotypes and alleles of PIP5K2A polymorphisms in patients with schizophrenia with different types of course of the disease

From: Genetic polymorphisms of PIP5K2A and course of schizophrenia

SNP	Genotype Allele	Frequency		Chi-square	p-value	OR	Cl 95%
SNP	Genotype Allele	Group of patients with a continuous course of schizophrenia (n = 269)	Group of patients with an episodic course of schizophrenia (n = 115)	Chi-square	p-value	OR	Cl 95%
rs10828317	CC	0.187	0.175	0.072	0.965	1.08	0.61–1.91
	CT	0.403	0.412			0.96	0.62–1.50
	TT	0.410	0.412			0.99	0.64–1.55
	C	0.388	0.382	0.030	0.870	1.03	0.75–1.41
	T	0.612	0.618			0.97	0.71–1.34
rs8341	CC	0.387	0.426	6.559	0.038	0.85	0.54–1.32
	CT	0.502	0.383			1.63	1.04–2.54
	TT	0.112	0.191			0.53	0.29–0.97
	C	0.638	0.617	0.280	0.600	1.09	0.79–1.50
	T	0.362	0.383			0.92	0.67–1.26
rs746203	CC	0.133	0.195	4.756	0.093	0.63	0.35–1.14
	CT	0.494	0.381			1.59	1.01–2.50
	TT	0.373	0.425			0.80	0.51–1.26
	C	0.380	0.385	0.010	0.900	0.98	0.71–1.35
	T	0.620	0.615			1.02	0.74–1.41
rs10430590	AA	0.467	0.437	1.754	0.416	0.76	0.46–1.25
	AT	0.434	0.402			1.14	0.68–1.89
	TT	0.099	0.061			1.70	0.62–4.60
	A	0.684	0.738	1.690	0.190	0.77	0.52–1.14
	T	0.316	0.262			1.30	0.87–1.94
rs946961	CC	0.108	0.023	5.976	0.049	5.17	1.20–22.21
	CG	0.478	0.529			0.82	0.50–1.33
	GG	0.414	0.448			0.87	0.53–1.42
	C	0.347	0.287	2.100	0.150	1.32	0.91–1.92
	G	0.653	0.713			0.76	0.52–1.10
rs1132816	AA	0.621	0.685	1.959	0.376	0.75	0.45–1.26
	AG	0.294	0.270			1.13	0.66–1.94
	GG	0.085	0.045			1.97	0.66–5.89
	A	0.768	0.820	2.080	0.150	0.73	0.47–1.12
	G	0.232	0.180			1.38	0.89–2.13
rs1417374	AA	0.129	0.151	3.735	0.154	0.83	0.41–1.67
	AG	0.469	0.349			1.65	0.99–2.75
	GG	0.402	0.500			0.67	0.41–1.10
	A	0.363	0.326	0.780	0.380	1.18	0.82–1.71
	G	0.637	0.674			0.85	0.59–1.22
rs943190	CC	0.131	0.209	5.326	0.070	0.57	0.30–1.08
	CT	0.502	0.372			1.70	1.03–2.81
	TT	0.367	0.419			0.80	0.49–1.32
	C	0.382	0.395	0.090	0.760	0.95	0.66–1.35
	T	0.618	0.605			1.06	0.74–1.51
rs943194	GG	0.118	0.123	0.506	0.776	0.95	0.44–2.06
	GT	0.489	0.444			1.20	0.72–1.99
	TT	0.392	0.432			0.85	0.51–1.42
	G	0.363	0.346	0.160	0.690	1.08	0.74–1.57
	T	0.637	0.654			0.93	0.64–1.35
rs1171506	AA	0.097	0.037	2.938	0.230	2.80	0.82–9.55
	AG	0.413	0.432			0.92	0.56–1.54
	GG	0.490	0.531			0.85	0.51–1.40
	A	0.304	0.253	1.510	0.220	1.29	0.86–1.93
	G	0.696	0.747			0.78	0.52–1.16
rs11013052	AA	0.083	0.048	1.762	0.414	1.82	0.61–5.46
	AC	0.365	0.333			1.15	0.68–1.94
	CC	0.552	0.619			0.76	0.46–1.25
	A	0.266	0.214	1.770	0.180	1.33	0.87–2.02
	C	0.734	0.786			0.75	0.50–1.14

Bold text indicates p-value< 0.05

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