Table 3 Odds ratios (OR) of the polymorphic rs17782313 MC4R genotypes for diabetes in the population
From: Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women
Normal | Diabetes b | ||||||
|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | ||||||
Subjects | Genotype | N (%) | N (%) | OR (95% CIa) | P-value | OR (95% CIb) | P-value |
All | TT | 2233 (57.6) | 195 (51.5) | 1.00 (reference) | 1.00 (reference) | ||
(n = 4259) | TC /CC | 1647 (42.4) | 184 (48.6) | 1.32 (1.07–1.64)* | 0.0113 | 1.29 (1.04–1.60) * | 0.0218 |
Men | TT | 1513 (58.2) | 151 (51.4) | 1.00 (reference) | 1.00 (reference) | ||
TC/ CC | 1089 (41.8) | 143 (48.6) | 1.34 (1.05–1.72) * | 0.0182 | 1.33 (1.04–1.70) * | 0.0219 | |
Women | TT | 720 (56.3) | 44 (51.8) | 1.00 (reference) | 1.00 (reference) | ||
TC/ CC | 558 (43.7) | 41 (48.2) | 1.25 (0.80–1.96) | 0.3337 | 1.10 (0.70–1.75) | 0.6878 | |
All Healthy | TT | 1357 (58.6) | 82 (50.9) | 1.00 (reference) | 1.00 (reference) | ||
(n = 2477) | TC /CC | 959 (41.4) | 79 (49.1) | 1.46 (1.05–2.02) * | 0.0234 | 1.40 (1.01–1.95) * | 0.0424 |
Men | TT | 887 (59.9) | 67 (54.9) | 1.00 (reference) | 1.00 (reference) | ||
TC/ CC | 594 (40.1) | 55 (45.1) | 1.27 (0.88–1.85) | 0.2082 | 1.24 (0.85–1.81) | 0.2580 | |
Women | TT | 470 (56.3) | 15 (38.5) | 1.00 (reference) | 1.00 (reference) | ||
TC/ CC | 365 (43.7) | 24 (61.5) | 2.13 (1.09–4.19) * | 0.0277 | 1.99 (1.01–3.93) * | 0.0490 | |