Table 2 Association between the rs17782313 single nucleotide polymorphism in the MC4R gene and fasting blood-sugar levels based on a linear regression model
From: Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women
Genotypes | |||||
|---|---|---|---|---|---|
Phenotypes | TT | TC | CC | Effect (mg/dL) | P-value |
Mean ± SD | Mean ± SD | Mean ± SD | |||
All subjects | (N = 2428) | (N = 1578) | (N = 253) | ||
Fasting blood sugar, mg/dL | 96.0 ± 21.3 | 98.6 ± 24.9 | 96.5 ± 18.4 | 1.542 | 0.0057* |
Body mass index, kg/m2 | 24.3 ± 2.9 | 24.5 ± 3.0 | 24.8 ± 3.2 | 0.227 | 0.0018* |
Weight, kg | 67.2 ± 11.0 | 67.6 ± 11.1 | 68.6 ± 11.1 | 0.739 | 0.0010* |
Systolic blood pressure, mmHg | 121.7 ± 14.6 | 122.0 ± 14.3 | 122.7 ± 15.0 | 0.452 | 0.2032 |
Diastolic blood pressure, mmHg | 78.2 ± 11.0 | 78.2 ± 10.4 | 78.4 ± 11.2 | 0.061 | 0.8184 |
% | % | % | |||
Cardiovascular disease | 40.7 | 44.1 | 38.3 | 0.0543 | |
Diabetes | 8.0 | 10.5 | 7.1 | 0.0153 | |
Healthy subjects | (N = 1439) | (N = 882) | (N = 156) | ||
Fasting blood sugar, mg/dL | 93.6 ± 18.5 | 96.3 ± 22.5 | 93.7 ± 13.3 | 1.477 | 0.0205* |
Body mass index, kg/m2 | 24.0 ± 2.9 | 24.2 ± 3.0 | 24.3 ± 2.6 | 0.237 | 0.0096* |
Weight, kg | 66.5 ± 11.2 | 66.9 ± 11.5 | 67.8 ± 10.6 | 0.839 | 0.0035* |
Systolic blood pressure, mmHg | 119.4 ± 13.5 | 119.3 ± 13.3 | 119.8 ± 12.1 | 0.156 | 0.7119 |
Diastolic blood pressure, mmHg | 78.8 ± 10.9 | 78.5 ± 10.5 | 78.8 ± 10.1 | −0.039 | 0.9068 |
% | % | % | |||
Diabetes | 5.7 | 8.1 | 5.1 | 0.0642 | |