First author, year, study | Cohort characteristics | Country | Gender (men/women) | BMI (mean ± SD) | Study design | Genotyping | Sample size | genotype | allele | HWE | PH-W | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | GC | GG | G | C | ||||||||||
Sood.V 2018 [5] | NAFLD children | India | case control study | 69 | 22 | 23 | 24 | 71 | 67 | no | 0.005 | |||
NON-NAFLD | 30 | 21 | 8 | 1 | 10 | 50 | yes | 0.82 | ||||||
Stasinou.E 2018 [6] | NAFLD children | Greece | case control study | RFLP | 58 | 8 | 10 | 40 | 90 | 26 | no | 0.0001 | ||
NON-NAFLD | 91 | 66 | 22 | 3 | 28 | 154 | yes | 0.49 | ||||||
Hudert.C 2018 [7] | NAFLD children | German | 54/16 | 35.9 ± 14.5 | case control study | TaqMan | 70 | 20 | 31 | 19 | 69 | 71 | yes | 0.339 |
NON-NAFLD | 123/77 | 200 | 118 | 71 | 11 | 93 | 307 | yes | 0.94 | |||||
Lin.Y-C 2014 [8] | NAFLD children | China | 555/242 | 27.0 ± 4.1 | case control study | TaqMan | 191 | 58 | 95 | 38 | 171 | 211 | yes | 0.93 |
NON-NAFLD | 115/47 | 26.75 ± 3.85 | 606 | 238 | 293 | 75 | 443 | 769 | yes | 0.29 | ||||
Shang.X-R 2015 [9] | NAFLD children | China | 459/406 | 20.72 ± 3.61 | case control study | Mass ARRAY | 162 | 60 | 74 | 28 | 130 | 194 | yes | 0.53 |
NON-NAFLD | 28.8 ± 2.8 | 865 | 338 | 418 | 109 | 636 | 1094 | yes | 0.24 | |||||
Bugianesi.E 2017 [10] | NASH | Italy | 28.2 ± 3.5 | case control study | TaqMan | 219 | 74 | 101 | 44 | 189 | 249 | yes | 0.37 | |
NAFL | 41/30 | 95 ± 6 | 69 | 36 | 30 | 3 | 36 | 102 | yes | 0.29 | ||||
Nobili.V 2014 [11] | NASH | Italy | 51/30 | 95 ± 6 | case control study | TaqMan | 71 | 48 | 23 | |||||
NAFL | 93/56 | 81 | 80 | 1 | ||||||||||
Valenti.L 2010 [12] | NASH | Italy | case control study | TaqMan | 69 | 1 | 44 | 23 | 90 | 46 | no | 0.0002 | ||
NAFL | 28.2 ± 3.6 | 81 | 64 | 17 | 0 | 17 | 145 | yes | 0.29 | |||||
Mosca.A 2018 [13] | NASH | Italy | 27.8 ± 6 | case control study | TaqMan | 25 | 5 | 13 | 7 | 27 | 23 | yes | 0.82 | |
NAFL | 9 | 9 | 0 | 0 | 0 | 18 |