Table 2 Detailed description of cavities in the wild type protein

1

126

101

ILE12, MET17, GLY61, SER62, GLY63, GLN67, HIS68, ASP90, ASN91, ARG223, PRO225.

2

89

59

ILE165, PHE166, GLU167, GLY168, ASP170, LYS172, ASN173, GLY174, LEU178, THR350, PHE351, HIS352, TYR353, TYR354.

3

62

32

GLU196, VAL199, LEU200, ASN203, THR211, ALA213, GLY278.

4

42

19

THR32, HIS33, PHE255, GLU257, ASN258, LEU368, VAL369.

5

41

19

SER161, ALA162, ILE165, ARG215, HIS282, TYR254.

6

40

19

PHE15, GLY221, PRO222, ARG223, ASP224, PRO229, THR378, SER381, LEU385.

7

38

17

LEU73, ARG76, TYR78, PHE118, ILE264, ALA267, GLU268

8

35

15

LYS155, LEU156, ILE157, LEU210, THR211, THR212, LEY276.

9

33

14

THR116, VAL117, PHE118, LYS155, ILE157, ALA267.

1

127

96

PHE13, MET17, SER62, GLY63, PHE64, GLN67, PHE89, ASP90, ASN91, ARG223.

2

99

29

LYS40, ASN42, GLU257, ASN258, HIS261, GLY262, LEU265, TYR365, GLN366, LEU368.

3

42

20

PHE166, GLU167, VAL169, LEU347, THR350.

4

37

16

VAL199, LEU200, ASN203, ASP204, THR211, GLY278.

5

36

16

LEU231, ILE232, PHE294, LEU295, ILE298.

6

36

16

VAL70, LEU74, VAL80, VAL82, ASN91, PRO92, GLN93, VAL94.