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Table 4 The associations between SNPs and euphoria associated with the first heroin use

From: Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence

Gene Variable/ID Weak(n = 628) Strong (n = 173) Pa OR, 95% CI Pb Exp(B), 95% CI
   Number Percent Number Percent     
TH rs10770140      0.047n   0.791  
  TT 538 85.7 150 86.7 0.729 1.091, 0.667–1.785 0.741 1.088, 0.659–1.798
  TC 90 7.2 21 12.1 0.460 1.211,0.728–2.012 0.460 1.215, 0.724–2.037
  CC 0 0.0 2 1.2 0.046n 1.012, 0.996–1.028 0.999 7,208,139,313, 0.000-
  T 1166 92.8 321 92.8 0.970 1.009, 0.637–1.598   
  C 90 7.2 25 7.2     
  rs10770141      0.035n   0.593  
  GG 544 86.6 153 88.4 0.529 1.181, 0.703–1.986 0.515 1.192, 0.702–2.025
  GA 84 6.7 18 10.4 0.299 1.329,0.775–2.278 0.283 1.351,0.780–2.342
  AA 0 0.0 2 1.2 0.046n 1.012, 0.996–1.028 0.999 7,208,139,313, 0.000-
  G 1172 93.3 324 93.6 0.827 0.947, 0.583–1.539   
  A 84 6.7 22 6.4     
  1. Pa: Genotypic and allele frequency difference assessment by chi-square test
  2. Pb: Genotypic and allele frequency difference assessment by binary logistic regression
  3. n: The result was not significant after Bonferroni’s correction