Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence

BMC Medical Genetics

Table 4 The associations between SNPs and euphoria associated with the first heroin use

Gene	Variable/ID	Weak(n = 628)		Strong (n = 173)		P^a	OR, 95% CI	P^b	Exp(B), 95% CI
		Number	Percent	Number	Percent
TH	rs10770140					0.047ⁿ		0.791
	TT	538	85.7	150	86.7	0.729	1.091, 0.667–1.785	0.741	1.088, 0.659–1.798
	TC	90	7.2	21	12.1	0.460	1.211,0.728–2.012	0.460	1.215, 0.724–2.037
	CC	0	0.0	2	1.2	0.046ⁿ	1.012, 0.996–1.028	0.999	7,208,139,313, 0.000-
	T	1166	92.8	321	92.8	0.970	1.009, 0.637–1.598
	C	90	7.2	25	7.2
	rs10770141					0.035ⁿ		0.593
	GG	544	86.6	153	88.4	0.529	1.181, 0.703–1.986	0.515	1.192, 0.702–2.025
	GA	84	6.7	18	10.4	0.299	1.329,0.775–2.278	0.283	1.351,0.780–2.342
	AA	0	0.0	2	1.2	0.046ⁿ	1.012, 0.996–1.028	0.999	7,208,139,313, 0.000-
	G	1172	93.3	324	93.6	0.827	0.947, 0.583–1.539
	A	84	6.7	22	6.4

P^a: Genotypic and allele frequency difference assessment by chi-square test
P^b: Genotypic and allele frequency difference assessment by binary logistic regression
ⁿ: The result was not significant after Bonferroni’s correction

ISSN: 1471-2350