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Fig. 2 | BMC Medical Genetics

Fig. 2

From: Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain

Fig. 2

POLE/Q/Z mutations in colorectal [38], endometrial (UCEC) and stomach (STAD) cancers. a Venn diagram displaying the number of cases with mutations in 1, 2 or 3 POL genes. b Mutation groups of cases without polymerase mutations (other), or with mutations in POLE only, E/Q, E/Z and E/Q/Z. The number of cases in each group is listed in parenthesis. The p-value for comparison of POLE and E/Q groups is not significant (p = 0.056) c Number of cases with mutations in POLE exonuclease domain in various mutation groups. d Percentages the ratio of transitions (Ti) and transversions (Tv) are shown on the Y-axis for CORE, STAD and UCEC. The x-axis shows the mutation groups

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BMC Medical Genetics

ISSN: 1471-2350

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