Skip to main content

Table 2 The distributions of the allele frequency and genotype in the included studies

From: The genome-wide supported CACNA1C gene polymorphisms and the risk of schizophrenia: an updated meta-analysis

Author Year Genotype distribution PHWE Allele frequency
ss   Cases, n Controls, n   Cases (%) Control (%)
   AA Aa aa AA Aa aa   A a A a
Rs1006737
Lubeiro 2018 25 23 2 58 38 5 0.70 73 (73.0) 27 (27.0) 154 (76.2) 48 (23.8)
Fatima 2017 393 84 17 235 54 9 0.01 870 (88.1) 118 (11.9) 524 (88.0) 72 (12.0)
Ivorra 2014 1417 1271 293 1420 1124 240 0.41 4105 (68.9) 1857 (31.1) 3964 (71.2) 1604 (28.8)
Galaktionova 2013 78 85 23 80 90 22 0.66 241 (64.8) 131 (35.2) 250 (65.1) 134 (34.9)
Nyegaard 2010 402 444 130 656 675 158 0.42 1248 (63.9) 704 (36.1) 1987 (66.7) 991 (33.3)
Bigos 2010 120 115 47 191 205 44 0.31 355 (62.9) 209 (37.1) 587 (66.7) 293 (33.3)
Green 2009 205 208 66 1367 1233 336 0.02 618 (64.5) 340 (35.5) 3967 (67.6) 1095 (32.4)
Mallas 2016 23 30 10 56 51 17 0.33 76 (60.3) 50 (39.7) 163 (65.7) 85 (34.3)
Porcelli 2015 153 23 0 301 23 2 0.11 329 (93.5) 23 (6.5) 625 (95.9) 27 (4.1)
He 2013 996 220 14 1053 166 9 0.39 2212 (89.9) 248 (10.1) 2272 (92.5) 184 (7.5)
Guan 2013 1061 343 26 1223 327 20 0.72 2465 (86.2) 395 (13.8) 2773 (88.3) 367 (11.7)
Zheng 2013 5239 635 19 5706 597 16 0.93 11,113 (94.3) 673 (5.7) 12,009 (95.0) 629 (5.0)
Hori 2012 480 70 2 1002 127 3 0.63 1030 (93.3) 74 (6.7) 2131 (94.1) 133 (5.9)
Zhang 2011 280 37 1 357 42 2 0.53 597 (93.9) 39 (6.1) 756 (94.3) 46 (5.7)
Rs2007044
Zhang 2018 24 25 4 58 57 14 1.00 73 (68.9) 33 (31.1) 173 (67.1) 85 (32.9)
Bustillo 2017 26 23 9 35 21 11 0.02 75 (64.7) 41 (35.3) 91 (67.9) 43 (32.1)
Zheng 2014 2797 2540 559 3166 2597 559 0.42 8134 (77.5) 3658 (22.5) 8929 (70.7) 3715 (29.3)
Rs4765905
Sudesh 2018 579 307 51 668 286 38 0.29 1465 (78.2) 409 (21.8) 1622 (81.8) 362 (18.2)
Guan 2013 1307 360 33 1195 352 24 0.74 2434 (71.6) 426 (28.4) 2741 (87.2) 399 (12.8)
  1. Notes:PHWE, P-value of the Hardy–Weinberg equilibrium; A, wild-type allele; a, mutant allele