Table 3 Associations between biochemical biomarkers and APOE E4 and E2 variants
From: APOE – a genetic marker of comorbidity in subjects with morbid obesity
Biochemical biomarkers | APOE-E4 Present (no 55) | APOE-E4 Absent (no 85) | Statistics p-value | Adjusted* B-value (CI) p-value | APOE-E2 Present (no 18) | APOE-E2 Absent (no 122) | Statistics p-value | Adjusted* B-value (CI) p-value |
|---|---|---|---|---|---|---|---|---|
Hb (no 139) | 14.6 (1.1) | 14.4 (1.1) | P = 0.23 | 0.24 (−0.06;0.54) P = 0.12 | 14.6 (1.2) | 14.5 (1.1) | p = 0.57 | 0.09 (−0.36;0.53) p = 0.70 |
CRP at inclusion (no 139) | 5.3 (4.6) | 8.2 (7.1) | p = 0.004 | −2.98 (−5.06;-0.91) p = 0.005 | 9.6 (7.7) | 6.7 (6.1) | p = 0.07 | 2.80 (−0.27;5.87) p = 0.07 |
CRP before surgery (no 108) | 3.1 (2.8) | 5.2 (4.4) | p = 0.007 | −1.65 (−3.12;-0.19) p = 0.028 | 7.1 (7.1) | 4.0 (3.0) | p = 0.112 | 3.46 (1.48;5.42) p = 0.001 |
CRP 1 year after surgery (no 88) | 0.7 (0.8) | 1.3 (1.6) | p = 0.032 | −0.53 (−1.13;0.07) p = 0.08 | 2.3 (2.4) | 0.9 (1.0) | p = 0.062 | 1.55 (0.77;2.33) p < 0.001 |
HbA1C (no 139) | 5.9 (1.4) | 5.8 (1.3) | p = 0.62 | 0.14 (−0.32;0.60) p = 0.54 | 6.5 (2.0) | 5.8 (1.2) | P = 0.133 | 0.79 (0.14;1.44) p = 0.018 |
HDL cholesterol (no 139) | 1.2 (0.4) | 1.2 (0.3) | p = 0.69 | 0.03 (−0.08;0.13) p = 0.64 | 1.1 (0.3) | 1.2 (0.3) | p = 0.25 | −0.07 (− 0.22;0.09) p = 0.38 |
LDL cholesterol (no 139) | 3.5 (0.8) | 3.3 (0.8) | p = 0.08 | 0.25 (−0.04;0.55) p = 0.09 | 3.0 (1.0) | 3.4 (0.8) | p = 0.06 | −0.41 (− 0.83;0.02) p = 0.06 |
Il-6 (no 134) | 2.5 (1.5) | 3.0 (3.5) | p = 0.32 | −0.52 (−1.55;0.51) p = 0.32 | 2.8 (1.4) | 2.8 (3.1) | p = 0.95 | −0.02 (−1.50;1.49) p = 0.98 |
TNF (no 135) | 11.4 (28.8) | 12.9 (49.5) | p = 0.84 | −1.25 (− 16.3;13.8) p = 0.87 | 6.6 (2.5) | 13.2 (45.7) | p = 0.54 | −5.7 (−27.2;15.9) p = 0.60 |