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Table 3 Associations between biochemical biomarkers and APOE E4 and E2 variants

From: APOE – a genetic marker of comorbidity in subjects with morbid obesity

Biochemical biomarkers APOE-E4
Present
(no 55)
APOE-E4
Absent
(no 85)
Statistics
p-value
Adjusted*
B-value (CI)
p-value
APOE-E2
Present
(no 18)
APOE-E2
Absent
(no 122)
Statistics
p-value
Adjusted*
B-value (CI)
p-value
Hb (no 139) 14.6 (1.1) 14.4 (1.1) P = 0.23 0.24 (−0.06;0.54)
P = 0.12
14.6 (1.2) 14.5 (1.1) p = 0.57 0.09 (−0.36;0.53)
p = 0.70
CRP at inclusion (no 139) 5.3 (4.6) 8.2 (7.1) p = 0.004 −2.98 (−5.06;-0.91)
p = 0.005
9.6 (7.7) 6.7 (6.1) p = 0.07 2.80 (−0.27;5.87)
p = 0.07
CRP before surgery (no 108) 3.1 (2.8) 5.2 (4.4) p = 0.007 −1.65 (−3.12;-0.19)
p = 0.028
7.1 (7.1) 4.0 (3.0) p = 0.112 3.46 (1.48;5.42)
p = 0.001
CRP 1 year after surgery (no 88) 0.7 (0.8) 1.3 (1.6) p = 0.032 −0.53 (−1.13;0.07)
p = 0.08
2.3 (2.4) 0.9 (1.0) p = 0.062 1.55 (0.77;2.33)
p < 0.001
HbA1C (no 139) 5.9 (1.4) 5.8 (1.3) p = 0.62 0.14 (−0.32;0.60)
p = 0.54
6.5 (2.0) 5.8 (1.2) P = 0.133 0.79 (0.14;1.44)
p = 0.018
HDL cholesterol (no 139) 1.2 (0.4) 1.2 (0.3) p = 0.69 0.03 (−0.08;0.13)
p = 0.64
1.1 (0.3) 1.2 (0.3) p = 0.25 −0.07 (− 0.22;0.09)
p = 0.38
LDL cholesterol (no 139) 3.5 (0.8) 3.3 (0.8) p = 0.08 0.25 (−0.04;0.55)
p = 0.09
3.0 (1.0) 3.4 (0.8) p = 0.06 −0.41 (− 0.83;0.02)
p = 0.06
Il-6 (no 134) 2.5 (1.5) 3.0 (3.5) p = 0.32 −0.52 (−1.55;0.51)
p = 0.32
2.8 (1.4) 2.8 (3.1) p = 0.95 −0.02 (−1.50;1.49)
p = 0.98
TNF (no 135) 11.4 (28.8) 12.9 (49.5) p = 0.84 −1.25 (− 16.3;13.8)
p = 0.87
6.6 (2.5) 13.2 (45.7) p = 0.54 −5.7 (−27.2;15.9)
p = 0.60
  1. The results are given as mean (SD). T-test was used for the comparisons. * Adjusted associations between the biochemical biomarkers (dependent variable) and APOE E4 and E2 were analysed with linear regression analyses adjusted for age, gender and BMI. The results are reported as unstandardized coefficients (B-value) with 95% confidence intervals and p-values