Table 2 Associations between comorbidity and APOE E4 and E2 variants
From: APOE – a genetic marker of comorbidity in subjects with morbid obesity
Subjects’ psychosomatic disorders (no is given if less than 140) | APOE-E4 Present (no 55) | APOE-E4 Absent (no 85) | Statistics p-value | Adjusted* p-value | APOE-E2 Present (no 18) | APOE-E2 Absent (no 122) | Statistics p-value | Adjusted* p-value |
|---|---|---|---|---|---|---|---|---|
Diabetes (no 135) | 12/54 (22%) | 14/81 (17%) | p = 0.51 | OR† 0.30 (0.55;3.33) p = 0.51 | 6/18 (33%) | 20/117 (17%) | 0.12 | OR† 0.92 (0.77;8.1) p = 0.12 |
Hypertension (no 135) | 19/54 (35%) | 27/81 (33%) | p = 0.85 | OR† 0.11 (0.051;2.48) p = 0.78 | 10/18 (56%) | 36/117 (31%) | 0.06 | OR† 1.34 (1.21;12.1) p = 0.022 |
Physical activity (no 134) | 4.5 (2.3) | 4.5 (2.2) | p = 0.84 | - 0.076 (−0.868;0.715) p = 0.85 | 5.1 (1.6) | 4.4 (2.3) | 0.15 | 0.666 (−0.465;1.798) p = 0.25 |
Musculoskeletal pain (no 137) | 4.5 (3.0) | 4.2 (2.9) | p = 0.66 | −0.21 (− 0.81;1.23) p = 0.68 | 2.8 (2.5) | 4.5 (3.0) | 0.020 | −1.74 (−3.23;-0.26) p = 0.022 |
WHO-5 Well-Being Index (no139) | 58.2 (18.5) | 59.8 (17.1) | p = 0.61 | −1.60 (−7.73;4.52) p = 0.61 | 70.4 (14.1) | 57.5 (17.5) | 0.003 | 12.89 (4.22;21.56) p = 0.004 |
Hopkins Symptom Checklist 10 (no 135) | 0.62 (0.57) | 0.57 (0.53) | p = 0.58 | 0.06 (−0.13;0.25) p = 0.54 | 0.27 (0.32) | 0.64 (0.56) | < 0.001 | −0.36 (− 0.62;-0.09) p = 0.009 |
Rosenberg Self-Esteem (no 131) | 24.7 (1.9) | 24.3 (1.8) | p = 0.24 | 0.37 (−0.29;1.02) p = 0.27 | 25.2 (1.6) | 24.3 (1.9) | 0.057 | 0..87 (−0.08;1.81) p = 0.07 |
Fatigue Severity Scale (no 137) | 36.6 (15.2) | 35.2 (14.6) | p = 0.61 | 1.34 (−3.75;6.43) p = 0.52 | 29.2 (13.3) | 36.7 (14.8) | 0.045 | −6.95 (− 14.22;0.32) p = 0.06 |
Epworth Sleepiness Scale (no138) | 8.9 (5.1) | 7.4 (4.3) | p = 0.06 | 1.52 (−0.09;3.12) p = 0.06 | 6.0 (2.1) | 8.3 (4.9) | 0.052 | −2.22 (− 4.54;0.11) p = 0.06 |
Sense of humour (no 138) | 19.6 (2.5) | 18.9 (2.8) | p = 0.12 | −0.71 (− 0.19;1.60) p = 0.12 | 18.9 (2.5) | 19.2 (2.7) | 0.70 | −0.36 (−1.67;0.96) p = 0.60 |