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Table 2 Associations between comorbidity and APOE E4 and E2 variants

From: APOE – a genetic marker of comorbidity in subjects with morbid obesity

Subjects’ psychosomatic disorders (no is given if less than 140) APOE-E4
Present
(no 55)
APOE-E4
Absent
(no 85)
Statistics
p-value
Adjusted*
p-value
APOE-E2
Present
(no 18)
APOE-E2
Absent
(no 122)
Statistics
p-value
Adjusted*
p-value
Diabetes (no 135) 12/54 (22%) 14/81 (17%) p = 0.51 OR† 0.30 (0.55;3.33)
p = 0.51
6/18 (33%) 20/117 (17%) 0.12 OR† 0.92 (0.77;8.1)
p = 0.12
Hypertension (no 135) 19/54 (35%) 27/81 (33%) p = 0.85 OR† 0.11 (0.051;2.48)
p = 0.78
10/18 (56%) 36/117 (31%) 0.06 OR† 1.34 (1.21;12.1)
p = 0.022
Physical activity (no 134) 4.5 (2.3) 4.5 (2.2) p = 0.84 - 0.076 (−0.868;0.715) p = 0.85 5.1 (1.6) 4.4 (2.3) 0.15 0.666 (−0.465;1.798) p = 0.25
Musculoskeletal pain (no 137) 4.5 (3.0) 4.2 (2.9) p = 0.66 −0.21 (− 0.81;1.23)
p = 0.68
2.8 (2.5) 4.5 (3.0) 0.020 −1.74 (−3.23;-0.26) p = 0.022
WHO-5 Well-Being Index (no139) 58.2 (18.5) 59.8 (17.1) p = 0.61 −1.60 (−7.73;4.52)
p = 0.61
70.4 (14.1) 57.5 (17.5) 0.003 12.89 (4.22;21.56) p = 0.004
Hopkins Symptom Checklist 10 (no 135) 0.62 (0.57) 0.57 (0.53) p = 0.58 0.06 (−0.13;0.25)
p = 0.54
0.27 (0.32) 0.64 (0.56) < 0.001 −0.36 (− 0.62;-0.09) p = 0.009
Rosenberg Self-Esteem (no 131) 24.7 (1.9) 24.3 (1.8) p = 0.24 0.37 (−0.29;1.02)
p = 0.27
25.2 (1.6) 24.3 (1.9) 0.057 0..87 (−0.08;1.81) p = 0.07
Fatigue Severity Scale (no 137) 36.6 (15.2) 35.2 (14.6) p = 0.61 1.34 (−3.75;6.43)
p = 0.52
29.2 (13.3) 36.7 (14.8) 0.045 −6.95 (− 14.22;0.32) p = 0.06
Epworth Sleepiness Scale (no138) 8.9 (5.1) 7.4 (4.3) p = 0.06 1.52 (−0.09;3.12)
p = 0.06
6.0 (2.1) 8.3 (4.9) 0.052 −2.22 (− 4.54;0.11) p = 0.06
Sense of humour (no 138) 19.6 (2.5) 18.9 (2.8) p = 0.12 −0.71 (− 0.19;1.60)
p = 0.12
18.9 (2.5) 19.2 (2.7) 0.70 −0.36 (−1.67;0.96) p = 0.60
  1. The results are given as mean (SD) or number (proportion). Chi-square and t-test were used for the comparisons. *Adjusted associations between the subjects’ psychosomatic disorders (dependent variable) and APOE E4 and E2 were analysed with linear and logistic regression analyses adjusted for age, gender and BMI. The results are reported as unstandardized coefficients (B-value) or †Odds Ratio (OR) with 95% confidence intervals and p-values