Table 1 The frequencies of cytokine alleles and genotypes in IVDD patients and healthy controls
Cytokine | Position | Alleles/ Genotypes | IVDD N (%) | Control (N = 140) N (%) | P-Value | OR | 95% CI |
|---|---|---|---|---|---|---|---|
IL-12 (N = 71) | -1188 (rs3212227) | A | 103 (72.5) | 204(72.9) | 1.00 | 0.98 | 0.63–1.55 |
C | 39 (27.5) | 76(27.1) | 1.00 | 1.02 | 0.65–1.58 | ||
AA | 40 (56.3) | 72(51.4) | 0.56 | 1.22 | 0.69–2.16 | ||
CA | 23 (32.4) | 60(42.9) | 0.18 | 0.64 | 0.35–1.16 | ||
CC | 8 (11.3) | 8(5.7) | 0.17 | 2.09 | 0.75–5.84 | ||
IFN-γ (N = 74) | + 874 (rs2430561) | A | 85 (57.4) | 140(50.7) | 0.22 | 1.31 | 088–1.96 |
T | 63 (42.6) | 136(49.3) | 0.22 | 0.88 | 0.51–1.31 | ||
AA | 26 (35.1) | 43(31.2) | 0.65 | 1.19 | 0.66–2.18 | ||
AT | 33 (44.6) | 54(39.1) | 0.47 | 1.25 | 0.71–2.19 | ||
TT | 15 (20.3) | 41(29.7) | 0.15 | 0.60 | 0.31–1.18 | ||
IL-2 (N = 74) | -330 (rs2069762) | G | 68 (46.0) | 110(39.6) | 0.21 | 1.31 | 0.88–1.97 |
T | 80 (54.0) | 168(60.4) | 0.21 | 0.76 | 0.50–1.13 | ||
GG | 4 (5.4) | 8(5.8) | 1.00 | 0.94 | 0.27–3.22 | ||
TG | 60 (81.1) | 94(67.6) | 0.05 | 2.05 | 1.03–4.06 | ||
TT | 10 (13.5) | 37(26.6) | 0.03 | 0.43 | 0.20–0.93 | ||
IL-2 (N = 74) | + 166 (rs2069763) | G | 113 (76.4) | 219(78.8) | 0.62 | 0.87 | 0.54–1.40 |
T | 35 (23.6) | 59(21.2) | 0.62 | 1.15 | 0.71–1.85 | ||
GG | 40 (54.1) | 82(59) | 0.56 | 0.82 | 0.46–1.44 | ||
GT | 33 (44.6) | 55(39.6) | 0.56 | 1.23 | 0.69–2.17 | ||
TT | 1 (1.4) | 2(1.4) | 1.00 | 0.94 | 0.08–10.52 |