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Table 1 The frequencies of cytokine alleles and genotypes in IVDD patients and healthy controls

From: Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

Cytokine Position Alleles/ Genotypes IVDD
N (%)
Control (N = 140)
N (%)
P-Value OR 95% CI
IL-12 (N = 71) -1188 (rs3212227) A 103 (72.5) 204(72.9) 1.00 0.98 0.63–1.55
C 39 (27.5) 76(27.1) 1.00 1.02 0.65–1.58
AA 40 (56.3) 72(51.4) 0.56 1.22 0.69–2.16
CA 23 (32.4) 60(42.9) 0.18 0.64 0.35–1.16
CC 8 (11.3) 8(5.7) 0.17 2.09 0.75–5.84
IFN-γ (N = 74) + 874 (rs2430561) A 85 (57.4) 140(50.7) 0.22 1.31 088–1.96
T 63 (42.6) 136(49.3) 0.22 0.88 0.51–1.31
AA 26 (35.1) 43(31.2) 0.65 1.19 0.66–2.18
AT 33 (44.6) 54(39.1) 0.47 1.25 0.71–2.19
TT 15 (20.3) 41(29.7) 0.15 0.60 0.31–1.18
IL-2 (N = 74) -330 (rs2069762) G 68 (46.0) 110(39.6) 0.21 1.31 0.88–1.97
T 80 (54.0) 168(60.4) 0.21 0.76 0.50–1.13
GG 4 (5.4) 8(5.8) 1.00 0.94 0.27–3.22
TG 60 (81.1) 94(67.6) 0.05 2.05 1.03–4.06
TT 10 (13.5) 37(26.6) 0.03 0.43 0.20–0.93
IL-2 (N = 74) + 166 (rs2069763) G 113 (76.4) 219(78.8) 0.62 0.87 0.54–1.40
T 35 (23.6) 59(21.2) 0.62 1.15 0.71–1.85
GG 40 (54.1) 82(59) 0.56 0.82 0.46–1.44
GT 33 (44.6) 55(39.6) 0.56 1.23 0.69–2.17
TT 1 (1.4) 2(1.4) 1.00 0.94 0.08–10.52