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Table 5 Association analysis of rs1043784 variant in BMP6 in cases and controls according to glaucoma types

From: Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin

Group Genetic Model Genotype Control
n (%)
Cases
n (%)
OR (95% CI) p AIC BIC p§
PACG Co-dominant T/T 184 (73.6) 71 (69.6) 1.00 0.75 429.2 440.8 0.73
C/T 57 (22.8) 27 (26.5) 1.23 (0.72–2.09)
C/C 9 (3.6) 4 (3.9) 1.15 (0.34–3.86)
Dominant T/T 184 (73.6) 71 (69.6) 1.00 0.45 427.2 434.9 0.66
C/T-C/C 66 (26.4) 31 (30.4) 1.22 (0.73–2.02)
Recessive T/T-C/T 241 (96.4) 98 (96.1) 1.00 0.89 427.8 435.5 0.63
C/C 9 (3.6) 4 (3.9) 1.09 (0.33–3.63)
Over-dominant T/T-C/C 193 (77.2) 75 (73.5) 1.00 0.47 427.2 435 0.5
C/T 57 (22.8) 27 (26.5) 1.22 (0.72–2.07)
Log-additive 1.16 (0.76–1.76) 0.5 427.3 435 0.85
PXG Co-dominant T/T 184 (73.6) 64 (67.4) 1.00 0.29 409.6 421.1 0.24
C/T 57 (22.8) 29 (30.5) 1.46 (0.86–2.48)
C/C 9 (3.6) 2 (2.1) 0.64 (0.13–3.04)
Dominant T/T 184 (73.6) 64 (67.4) 1.00 0.25 408.8 416.5 0.24
C/T-C/C 66 (26.4) 31 (32.6) 1.35 (0.81–2.26)
Recessive T/T-C/T 241 (96.4) 93 (97.9) 1.00 0.46 409.5 417.2 0.38
C/C 9 (3.6) 2 (2.1) 0.58 (0.12–2.72)
Over-dominant T/T-C/C 193 (77.2) 66 (69.5) 1.00 0.14 407.9 415.6 0.13
C/T 57 (22.8) 29 (30.5) 1.49 (0.88–2.52)
Log-additive 1.18 (0.76–1.83) 0.46 409.5 417.2 0.45
  1. Abbreviations: OR (95% CI) Odds ratio (95% confidence interval), AIC Akaike’s information criterion, BIC Bayesian information criterion, PACG primary angle-closure glaucoma, PXG pseudoexfoliation glaucoma
  2. §p-value adjusted for age and sex in overall group and by age in men and women groups