Table 3 Association analysis of rs12997 variant in ACVR1 with primary angle-closure glaucoma
Group | Genetic Model | Genotype | Control n (%) | PACG n (%) | OR (95% CI) | p | AIC | BIC | p§ |
|---|---|---|---|---|---|---|---|---|---|
Overall | Co-dominant | A/A | 110 (44.4) | 42 (41.6) | 1.00 | 0.009 | 416.5 | 428.1 | 0.02 |
A/G | 111 (44.8) | 35 (34.6) | 0.83 (0.49–1.39) | ||||||
G/G | 27 (10.9) | 24 (23.8) | 2.33 (1.21–4.48) | ||||||
Dominant | A/A | 110 (44.4) | 42 (41.6) | 1.00 | 0.64 | 423.7 | 431.4 | 0.900 | |
A/G-G/G | 138 (55.6) | 59 (58.4) | 1.12 (0.70–1.79) | ||||||
Recessive | A/A-A/G | 221 (89.1) | 77 (76.2) | 1.00 | 0.003* | 415.1 | 422.8 | 0.009 | |
G/G | 27 (10.9) | 24 (23.8) | 2.55 (1.39–4.69) | ||||||
Over-dominant | A/A-G/G | 137 (55.2) | 66 (65.3) | 1.00 | 0.081 | 420.9 | 428.6 | 0.062 | |
A/G | 111 (44.8) | 35 (34.6) | 0.65 (0.40–1.06) | ||||||
Log-additive | – | – | – | 1.36 (0.99–1.89) | 0.062 | 420.4 | 428.1 | 0.150 | |
Men | Co-dominant | A/A | 55 (41.0) | 22 (50.0) | 1.00 | 0.120 | 200.8 | 210.4 | 0.170 |
A/G | 62 (46.3) | 13 (29.6) | 0.52 (0.24–1.14) | ||||||
G/G | 17 (12.7) | 9 (20.4) | 1.32 (0.51–3.41) | ||||||
Dominant | A/A | 55 (41.0) | 22 (50.0) | 1.00 | 0.300 | 202.0 | 208.4 | 0.170 | |
A/G-G/G | 79 (59.0) | 22 (50.0) | 0.70 (0.35–1.38) | ||||||
Recessive | A/A-A/G | 117 (87.3) | 35 (79.5) | 1.00 | 0.220 | 201.6 | 207.9 | 0.540 | |
G/G | 17 (12.7) | 9 (20.4) | 1.77 (0.73–4.32) | ||||||
Over-dominant | A/A-G/G | 72 (53.7) | 31 (70.5) | 1.00 | 0.048 | 199.2 | 205.5 | 0.060 | |
A/G | 62 (46.3) | 13 (29.6) | 0.49 (0.23–1.01) | ||||||
Log-additive | – | – | – | 0.98 (0.60–1.58) | 0.920 | 203.1 | 209.4 | 0.530 | |
Women | Co-dominant | A/A | 55 (48.2) | 20 (35.1) | 1.00 | 0.010 | 214.5 | 224 | 0.006 |
A/G | 49 (43.0) | 22 (38.6) | 1.23 (0.60–2.53) | ||||||
G/G | 10 (8.8) | 15 (26.3) | 4.12 (1.60–10.66) | ||||||
Dominant | A/A | 55 (48.2) | 20 (35.1) | 1.00 | 0.100 | 219 | 225.3 | 0.140 | |
A/G-G/G | 59 (51.8) | 37 (64.9) | 1.72 (0.89–3.32) | ||||||
Recessive | A/A-A/G | 104 (91.2) | 42 (73.7) | 1.00 | 0.003* | 212.9 | 219.1 | 0.002 | |
G/G | 10 (8.8) | 15 (26.3) | 3.71 (1.55–8.93) | ||||||
Over-dominant | A/A-G/G | 65 (57.0) | 35 (61.4) | 1.00 | 0.58 | 221.4 | 227.7 | 0.420 | |
A/G | 49 (43.0) | 22 (38.6) | 0.83 (0.44–1.60) | ||||||
Log-additive | – | – | – | 1.85 (1.17–2.92) | 0.0076 | 214.6 | 220.8 | 0.008 |