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Table 3 Association analysis of rs12997 variant in ACVR1 with primary angle-closure glaucoma

From: Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin

Group Genetic Model Genotype Control
n (%)
PACG
n (%)
OR (95% CI) p AIC BIC p§
Overall Co-dominant A/A 110 (44.4) 42 (41.6) 1.00 0.009 416.5 428.1 0.02
A/G 111 (44.8) 35 (34.6) 0.83 (0.49–1.39)
G/G 27 (10.9) 24 (23.8) 2.33 (1.21–4.48)
Dominant A/A 110 (44.4) 42 (41.6) 1.00 0.64 423.7 431.4 0.900
A/G-G/G 138 (55.6) 59 (58.4) 1.12 (0.70–1.79)
Recessive A/A-A/G 221 (89.1) 77 (76.2) 1.00 0.003* 415.1 422.8 0.009
G/G 27 (10.9) 24 (23.8) 2.55 (1.39–4.69)
Over-dominant A/A-G/G 137 (55.2) 66 (65.3) 1.00 0.081 420.9 428.6 0.062
A/G 111 (44.8) 35 (34.6) 0.65 (0.40–1.06)
Log-additive 1.36 (0.99–1.89) 0.062 420.4 428.1 0.150
Men Co-dominant A/A 55 (41.0) 22 (50.0) 1.00 0.120 200.8 210.4 0.170
A/G 62 (46.3) 13 (29.6) 0.52 (0.24–1.14)
G/G 17 (12.7) 9 (20.4) 1.32 (0.51–3.41)
Dominant A/A 55 (41.0) 22 (50.0) 1.00 0.300 202.0 208.4 0.170
A/G-G/G 79 (59.0) 22 (50.0) 0.70 (0.35–1.38)
Recessive A/A-A/G 117 (87.3) 35 (79.5) 1.00 0.220 201.6 207.9 0.540
G/G 17 (12.7) 9 (20.4) 1.77 (0.73–4.32)
Over-dominant A/A-G/G 72 (53.7) 31 (70.5) 1.00 0.048 199.2 205.5 0.060
A/G 62 (46.3) 13 (29.6) 0.49 (0.23–1.01)
Log-additive 0.98 (0.60–1.58) 0.920 203.1 209.4 0.530
Women Co-dominant A/A 55 (48.2) 20 (35.1) 1.00 0.010 214.5 224 0.006
A/G 49 (43.0) 22 (38.6) 1.23 (0.60–2.53)
G/G 10 (8.8) 15 (26.3) 4.12 (1.60–10.66)
Dominant A/A 55 (48.2) 20 (35.1) 1.00 0.100 219 225.3 0.140
A/G-G/G 59 (51.8) 37 (64.9) 1.72 (0.89–3.32)
Recessive A/A-A/G 104 (91.2) 42 (73.7) 1.00 0.003* 212.9 219.1 0.002
G/G 10 (8.8) 15 (26.3) 3.71 (1.55–8.93)
Over-dominant A/A-G/G 65 (57.0) 35 (61.4) 1.00 0.58 221.4 227.7 0.420
A/G 49 (43.0) 22 (38.6) 0.83 (0.44–1.60)
Log-additive 1.85 (1.17–2.92) 0.0076 214.6 220.8 0.008
  1. §p-value adjusted for age and sex in overall group and by age in men and women groups; *Best-fit model p-value. Abbreviations: AIC Akaike’s information criterion, BIC Bayesian information criterion, OR (95% CI) Odds ratio (95% confidence interval), PACG primary angle-closure glaucoma. Note: Significant odds ratio and p-value in bold. Bonferroni corrected p-value is 0.01