Association of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta-analysis

BMC Medical Genetics

Table 2 Association of genetic models of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk

Genotype/Allele	Cases	Controls	OR (95% CI)	P
Genotype/Allele	N = 60	N = 60	OR (95% CI)	P
A1A1	27 (45.0)	39 (65.0)	Reference
A1A2	25 (41.7)	16 (26.7)	2.25 (1.01–5.01)	0.04
A2A2	8 (13.3)	5 (8.3)	2.31 (0.68–7.83)	0.17
A2A2 + A1A2	33 (55.0)	21 (35.0)	2.26 (1.08–4.73)	0.02
A1A1 + A1A2	52 (86.7)	55 (91.7)	Reference
A2A2	8 (13.3)	5 (8.3)	1.69 (0.52–5.50)	0.38
A1	79 (65.8)	94 (78.3)	Reference
A2	41 (34.2)	26 (21.7)	1.87 (1.05–3.33)	0.03

N Number, CI confidence Interval, P p-value, A2A2 + A1A2 vs. A1A1: Dominant model, A2A2 vs. A1A1 + A1A2: Recessive model; A2 vs. A1: Additive model.

ISSN: 1471-2350