Skip to main content

Table 2 BMI levels in subgroups defined by the investigated genotypes

From: Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations

  

Allele

BMI (kg/m2)

Gene

SNP

ref.

var.

ref. homo-zygote.

minor allele carriers

p

NADSYN1

rs7935125

C

A

25.3 ± 4.2

26.0 ± 4.5

0.31

GC

rs17467825

A

G

26.4 ± 4.6

25.6 ± 4.4

0.045

rs222054

C

G

25.9 ± 4.5

26.1 ± 4.6

0.76

rs4588

G

T

26.4 ± 4.6

25.6 ± 4.4

0.048

rs7041

A

C

25.4 ± 4.1

26.2 ± 4.6

0.13

CYP2R1

rs1993116

A

G

26.5 ± 4.5

25.9 ± 4.5

0.295

rs10500804

T

G

26.4 ± 4.6

25.8 ± 4.5

0.15

rs11023374

T

C

26.5 ± 4.4

25.3 ± 4.4

0.006a

CYP24A1

rs4809959

A

G

25.9 ± 4.1

26.0 ± 4.6

0.89

rs927650

T

C

26.0 ± 4.4

25.9 ± 4.5

0.89

rs4809960

T

C

26.1 ± 4.4

25.8 ± 4.7

0.49

rs2209314

T

C

25.9 ± 4.4

26.2 ± 4.8

0.41

rs6022999

A

G

26.1 ± 4.3

25.8 ± 4.8

0.54

rs2181874

G

A

25.8 ± 4.3

26.2 ± 4.8

0.37

rs2585428

C

T

25.9 ± 4.1

26.0 ± 4.7

0.72

rs3787555

C

A

26.4 ± 4.4

25.5 ± 4.6

0.038

rs2762939

G

C

25.7 ± 4.4

26.4 ± 4.6

0.11

rs2244719

C

T

26.1 ± 4.0

25.9 ± 4.7

0.74

rs2762941

G

A

25.7 ± 4.3

26.1 ± 4.6

0.37

VDR

rs1544410

G

A

26.1 ± 4.4

25.9 ± 4.6

0.64

rs3890733

C

T

26.3 ± 4.8

25.8 ± 4.3

0.20

rs2853564

G

A

24.5 ± 4.3

26.2 ± 4.5

0.007a

rs7302235

T

C

25.5 ± 4.2

26.6 ± 4.9

0.017a

  1. Univariate associations between SNPs and BMI were analyzed using two-sample t-tests
  2. a marks association that remained significant after FDR correction
  3. Abbreviations: CYP24A1 vitamin D 24-hydroxylase gene (cytochrome P450 family 24 subfamily A member 1), CYP2R1 vitamin D 25-hydroxylase gene (cytochrome P450 family 2 subfamily R member 1), GC vitamin D binding protein, “group-specific component” gene, NADSYN1 glutamine-dependent NAD(+) synthetase, VDR vitamin D receptor
  4. Bold text highlights where p < 0.05
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us