Table 4 The relationship of three gene polymorphisms with liver cancer according to the stratification by gender and age
From: MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population
SNP | Model | Genotype | Male | Female | > 55 | ≤55 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | p | OR (95%CI) | p | OR (95%CI) | p | OR (95%CI) | p | |||
rs12482371 | Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
C | 0.79 (0.63 - 1.00) | 0.046 | 1.11 (0.71 - 1.76) | 0.642 | 0.88 (0.65 - 1.19) | 0.410 | 0.81 (0.61 - 1.08) | 0.155 | ||
Genotype | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CT | 0.93 (0.68 - 1.28) | 0.651 | 1.55 (0.83 - 2.92) | 0.170 | 1.08 (0.71 - 1.65) | 0.718 | 0.97 (0.66 - 1.43) | 0.895 | ||
CC | 0.51 (0.29 - 0.88) | 0.016* | 0.82 (0.29 - 2.36) | 0.716 | 0.60 (0.30 - 1.21) | 0.156 | 0.52 (0.26 - 1.04) | 0.063 | ||
Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CT-CC | 0.83 (0.62 - 1.13) | 0.236 | 1.38 (0.76 - 2.49) | 0.293 | 0.97 (0.65 - 1.44) | 0.871 | 0.87 (0.60 - 1.26) | 0.460 | ||
Recessive | TT-CT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CC | 0.52 (0.31 - 0.90) | 0.018* | 0.67 (0.24 - 1.86) | 0.448 | 0.58 (0.30 - 1.14) | 0.112 | 0.52 (0.27 - 1.03) | 0.059 | ||
Log-additive | – | 0.79 (0.63 - 1.00) | 0.049 | 1.11 (0.71 - 1.74) | 0.648 | 0.88 (0.65 - 1.19) | 0.395 | 0.82 (0.62 - 1.08) | 0.161 | |
rs1893650 | Allele | T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
C | 0.85 (0.65 - 1.11) | 0.224 | 1.22 (0.70 - 2.12) | 0.481 | 1.01 (0.71 - 1.44) | 0.956 | 0.82 (0.59 - 1.15) | 0.252 | ||
Genotype | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CT | 0.99 (0.71 - 1.36) | 0.929 | 1.43 (0.75 - 2.72) | 0.279 | 1.13 (0.74 - 1.73) | 0.577 | 1.00 (0.67 - 1.48) | 0.984 | ||
CC | 0.32 (0.11 - 0.90) | 0.030* | 0.55 (0.05 - 6.25) | 0.627 | 0.66 (0.20 - 2.14) | 0.491 | 0.10 (0.01 - 0.80) | 0.030* | ||
Dominant | TT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CT-CC | 0.91 (0.66 - 1.24) | 0.537 | 1.36 (0.72 - 2.56) | 0.339 | 1.08 (0.71 - 1.63) | 0.719 | 0.89 (0.61 - 1.32) | 0.570 | ||
Recessive | TT-CT | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CC | 0.32 (0.12 - 0.90) | 0.030* | 0.49 (0.04 - 5.51) | 0.560 | 0.63 (0.20 - 2.04) | 0.445 | 0.10 (0.01 - 0.79) | 0.029* | ||
Log-additive | – | 0.84 (0.64-1.11) | 0.212 | 1.24 (0.69 - 2.23) | 0.464 | 1.01 (0.71 - 1.46) | 0.941 | 0.80 (0.56 - 1.13) | 0.206 | |
rs928883 | Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
A | 1.17 (0.94 - 1.45) | 0.155 | 1.20 (0.78-1.83) | 0.406 | 1.12 (0.85 - 1.49) | 0.420 | 1.22 (0.94 - 1.59) | 0.130 | ||
Genotype | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AG | 1.95 (1.34 - 2.82) | 0.000* | 1.11 (0.55 - 2.23) | 0.766 | 1.84 (1.14 - 2.98) | 0.013* | 1.62 (1.03 - 2.55) | 0.036* | ||
AA | 1.34 (0.86 - 2.09) | 0.203 | 1.54 (0.62 - 3.87) | 0.356 | 1.20 (0.66 - 2.17) | 0.547 | 1.53 (0.88 - 2.65) | 0.130 | ||
Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AG-AA | 1.74 (1.23 - 2.48) | 0.002* | 1.20 (0.62 - 2.34) | 0.588 | 1.63 (1.03 - 2.58) | 0.036* | 1.59 (1.04 - 2.45) | 0.034* | ||
Recessive | GG-AG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA | 0.85 (0.59 - 1.23) | 0.399 | 1.44 (0.65 - 3.19) | 0.370 | 0.80 (0.49 - 1.31) | 0.373 | 1.10 (0.70 - 1.74) | 0.671 | ||
Log-additive | – | 1.18 (0.95 - 1.47) | 0.144 | 1.22 (0.78 - 1.92) | 0.381 | 1.13 (0.84 - 1.52) | 0.408 | 1.25 (0.95 - 1.65) | 0.106 | |