MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population

BMC Medical Genetics

Table 3 Relationships between MIR155HG polymorphism and liver cancer risk

SNP ID	Model	Genotype	Case (number)	Control (number)	Before adjusted		After adjusted		Power
SNP ID	Model	Genotype	Case (number)	Control (number)	OR (95%CI)	p^a	OR (95%CI)	p^b	Power
rs12482371	Genotype	TT	217	208	1.00		1.00		68.97%
		CT	185	171	1.04 (0.78 - 1.38)	0.801	1.04 (0.78 - 1.37)	0.801
		CC	30	51	0.56 (0.35 - 0.92)	0.022^*	0.56 (0.35 - 0.92)	0.022^*
	Dominant	TT	217	208	1.00		1.00
	Dominant	CT-CC	215	222	0.93 (0.71 - 1.21)	0.585	0.93 (0.71 - 1.21)	0.586
	Recessive	TT-CT	402	379	1.00		1.00
	Recessive	CC	30	51	0.55 (0.35 - 0.89)	0.014^*	0.55 (0.35 - 0.89)	0.015^*
	Log-additive	–	–	–	0.85 (0.70 - 1.05)	0.129	0.85 (0.70 - 1.05)	0.129
rs1893650	Genotype	TT	281	279	1.00		1.00		63.95%
		CT	145	135	1.07 (0.80 - 1.42)	0.661	1.07 (0.80 - 1.42)	0.663
		CC	6	17	0.35 (0.14 - 0.90)	0.030^*	0.35 (0.14 - 0.90)	0.030^*
	Dominant	TT	281	279	1.00		1.00
	Dominant	CT-CC	151	152	0.99 (0.75 - 1.30)	0.923	0.99 (0.75 - 1.3)	0.922
	Recessive	TT-CT	426	414	1.00		1.00
	Recessive	CC	6	17	0.34 (0.13 - 0.88)	0.026^*	0.34 (0.13 - 0.88)	0.026^*
	Log-additive	–	–	–	0.91 (0.71 - 1.16)	0.433	0.90 (0.71 - 1.16)	0.432
rs928883	Genotype	GG	90	129	1.00		1.00		97.12%
		AG	244	204	1.71 (1.24 - 2.38)	0.001^*	1.71 (1.24 - 2.38)	0.001^*
		AA	85	90	1.35 (0.91 - 2.02)	0.138	1.35 (0.9 - 2.02)	0.141
	Dominant	GG	90	129	1.00		1.00
	Dominant	AG-AA	329	294	1.60 (1.17 - 2.19)	0.003^*	1.60 (1.17 - 2.19)	0.003^*
	Recessive	GG-AG	334	333	1.00		1.00
	Recessive	AA	85	90	0.94 (0.67 - 1.31)	0.723	0.94 (0.67 - 1.31)	0.716
	Log-additive	–	–	–	1.19 (0.97 - 1.45)	0.088	1.19 (0.97 - 1.45)	0.090

OR odds ratio, SNP single-nucleotide polymorphism, 95% CI 95% confidence interval. ^ap values were calculated from unconditional logistic regression analysis. ^bp values were adjusted by age and gender
*p < 0.05 indicates statistical significance
*p < 0.0002 (0.05/8/4) indicates statistical significance for Bonferroni correction

ISSN: 1471-2350