Fig. 2
From: A novel SPAST gene mutation identified in a Chinese family with hereditary spastic paraplegia
Tertiary structure alteration prediction of SPAST by RaptorX tool. a. The tertiary structure of native protein. b. Tertiary structure of p.K570del affected protein. The novel mutation we reported resulted in the synthesis of misfolded protein. c. The spastin protein sequence alignment across species showing the area of this in-frame amino acid deletion (red frame) and the surrounding residues