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Table 3 Clinical findings of the MPS II patients

From: The mutational spectrum of hunter syndrome reveals correlation between biochemical and clinical profiles in Tunisian patients

MPS II patientsP1P2P3P4P5P6P7P8P9P10P11P12
Age at diagnosis (year/month)41/64634/24323912
Age (years)41822265579 (died)9 (died)19 (died)29 (died)39 (died)
Recurrent clinical symptoms
Hepatosplenomegaly+++++++++++++++++++ ++
Coarse facies: Broad noses, Macroglossia++++++++++++++++++++++++
Cranial dysmorphism: macrocrania+++++++++++++++++++++++++
Psychomotor retardation++++++++++++++++++++++++++++
multiple dysostosis: joint stiffness, oval vertebrae++++++++++++++++++++++++++++++++
Mental retardation++++++++++++++++++   ++
Respiratory problems: nasal obstruction, sleep apnea++++++++++++++++++++++++++++
Causes aggravating respiratory problems: otitis, large language and adenoids.++++++++++++++++++++++++++++
Cardiovascular involvement: arrhythmia and congestive heart failure+++++++++++++++++++++++++
Specific clinical symptoms
 Multiple hernia  Blood smear shows an overloadBlood smear shows an overload Dysphasia Skin involvement    Rhinorrhea umbilical hernia