HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects

Liu, Ying; Jin, Huipeng; Wei, Dong; Li, Wenxiu

doi:10.1186/s12881-020-01047-5

BMC Medical Genetics

Table 2 Characteristics of included studies in HTRA1 rs11200638 polymorphism and wet/dry AMD risk, respectively

From: HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects

Author	Year	Country	Ethnicity	type	Case	Control	SOC	Cases			Controls			HWE	Genotype
								AA	AG	GG	AA	AG	GG
Lin	2008	China-Taiwan	Asian	dry	52	90	HB	28	19	5	19	47	24	0.651	Sequencing
Chan	2007	USA	Caucasian	dry	18	13	HB	4	10	4	0	8	5	0.109	RT-PCR
Mori	2007	Japan	Asian	dry	19	116	HB	4	7	8	5	41	70	0.743	Sequencing
Askari	2015	Iran	Asian	dry	32	120	HB	11	12	9	12	66	42	0.576	Sequencing
Ruamviboonsuk	2017	Thailand	Asian	wet	377	1073	PB	125	164	88	146	490	437	0.643	InfiniumOmniExpressExome-8 v1.3 platform
Cheng	2013	China	Asian	wet	93	93	HB	52	30	11	21	42	30	0.395	Sequencing
Ng	2016	Hong Kong	Asian	wet	194	183	PB	109	63	22	38	90	55	0.915	Sequencing
Liang	2012	China	Asian	wet	161	150	HB	61	83	17	30	72	48	0.75	Sequencing
Chu	2008	China	Asian	wet	144	126	HB	76	52	16	31	69	26	0.276	PCR-RFLP
Jiang	2008	China	Asian	wet	159	140	HB	99	47	13	31	67	42	0.662	Sequencing
Lee	2010	Korea	Asian	wet	137	187	HB	57	59	21	35	100	52	0.283	Sequencing
Lin	2008	China-Taiwan	Asian	wet	43	90	HB	25	14	4	19	47	24	0.651	Sequencing
Xu	2007	China	Asian	wet	121	132	HB	56	52	13	24	64	44	0.931	Sequencing
Tam	2008	China-Hong Kong	Asian	wet	163	183	HB	94	51	18	38	90	55	0.916	Sequencing
Chan	2007	USA	Caucasian	wet	31	13	HB	8	16	7	0	8	5	0.109	RT-PCR
Leveziel	2007	France	Caucasian	wet	118	116	HB	32	57	29	5	41	70	0.743	TaqMan
Mori	2007	Japan	Asian	wet	104	116	HB	41	45	18	5	41	70	0.743	Sequencing
Askari	2015	Iran	Asian	wet	88	120	HB	47	30	11	12	66	42	0.576	Sequencing
Weger	2007	Austria	Caucasian	wet	242	157	PB	67	108	67	8	50	99	0.609	TaqMan
Lu	2007	China	Asian	wet	90	106	HB	53	34	3	15	63	28	< 0.05	PCR-RFLP
Mohamad	2019	Malaysia	Asian	wet	145	145	HB	79	47	19	48	82	15	< 0.05	PCR-RFLP
Yang	2010	China	Asian	wet	109	150	HB	31	45	33	30	50	70	< 0.05	PCR-RFLP
Chen	2008	USA	Caucasian	wet	470	294	HB	76	245	149	10	128	156	< 0.05	Sequencing
Chen	2008	USA	Caucasian	dry	306	294	HB	55	155	96	10	128	156	< 0.05	Sequencing
Zeng	2011	China	Caucasian	dry	341	509	PB	60	166	115	21	181	307	0.374	SNaPshot
Zeng	2011	China	Caucasian	wet	994	509	PB	184	475	335	21	181	307	0.374	SNaPshot
Matuskova	2020	Czech Republic	Caucasian	wet	307	191	HB	69	148	90	9	66	116	0.921	SNaPshot Multiplex-System

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