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Table 1 Characteristics of included studies in HTRA1 rs11200638 polymorphism and AMD risk

From: HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects

Author Year Country Ethnicity type Case Control SOC Cases    Controls    HWE Genotype
         AA AG GG AA AG GG   
Tian 2012 China Asian AMD 532 468 HB 255 193 84 104 224 140 0.423 Typer 4.0 software
Ruamviboonsuk 2017 Thailand Asian wet 377 1073 PB 125 164 88 146 490 437 0.643 InfiniumOmniExpressExome-8 v1.3 platform
Chu 2008 China Asian wet 144 126 HB 76 52 16 31 69 26 0.276 PCR-RFLP
Losonczy 2011 Hungary Caucasian AMD 103 95 HB 23 50 30 3 49 43 0.133 PCR-RFLP
Tuo 2008 USA Caucasian AMD 142 132 PB 33 60 49 7 51 74 0.638 PCR-RFLP
Tuo 2008 USA Caucasian AMD 330 191 PB 63 164 103 12 73 106 0.904 PCR-RFLP
Tuo 2008 USA Caucasian AMD 272 555 PB 15 122 135 20 186 349 0.431 PCR-RFLP
Tuo 2008 USA Caucasian AMD 46 22 PB 2 15 29 1 6 15 0.696 PCR-RFLP
Chan 2007 USA Caucasian AMD 52 13 HB 14 27 11 0 8 5 0.109 RT-PCR
Kanda 2007 USA Caucasian AMD 457 280 HB 102 183 172 11 90 179 0.94 RT-PCR
Cheng 2013 China Asian wet 93 93 HB 52 30 11 21 42 30 0.395 Sequencing
Liang 2012 China Asian wet 161 150 HB 61 83 17 30 72 48 0.751 Sequencing
Jiang 2008 China Asian wet 159 140 HB 99 47 13 31 67 42 0.662 Sequencing
Lee 2010 Korea Asian wet 137 187 HB 57 59 21 35 100 52 0.283 Sequencing
Lin 2008 China-Taiwan Asian AMD 95 90 HB 53 33 9 19 47 24 0.651 Sequencing
Kaur 2008 India Asian AMD 229 184 HB 90 89 50 21 85 78 0.765 Sequencing
Xu 2007 China Asian wet 121 132 HB 56 52 13 24 64 44 0.931 Sequencing
Tam 2008 China-Hong Kong Asian wet 163 183 HB 94 51 18 38 90 55 0.916 Sequencing
Mori 2007 Japan Asian AMD 123 133 HB 45 52 26 22 57 54 0.298 Sequencing
Askari 2015 Iran Asian AMD 120 120 HB 58 42 20 12 66 42 0.057 Sequencing
Lana 2018 Brazil Caucasian AMD 204 166 HB 73 89 42 22 77 67 0.987 Sequencing
Kaur 2013 India Asian AMD 198 145 PB 84 70 44 17 67 61 0.829 Sequencing
Ng 2016 Hong Kong Asian wet 194 183 PB 109 63 22 38 90 55 0.916 Sequencing
Kaur 2013 India Caucasian AMD 616 426 PB 130 292 194 17 138 271 0.913 Sequencing
Chen 2013 China Asian AMD 158 157 HB 28 74 56 21 77 59 0.599 TaqMan
Kondo 2007 Japan Asian AMD 73 94 HB 29 39 5 16 40 38 0.334 TaqMan
Leveziel 2007 France Caucasian wet 118 116 HB 32 57 29 5 41 70 0.743 TaqMan
Weger 2007 Austria Caucasian wet 242 157 PB 67 108 67 8 50 99 0.609 TaqMan
Lu 2007 China Asian wet 90 106 HB 53 34 3 15 63 28 < 0.05 PCR-RFLP
Cruz-González 2013 Spain Caucasian AMD 121 91 HB 29 60 32 61 21 9 < 0.05 PCR-RFLP
Mohamad 2019 Malaysia Asian wet 145 145 HB 79 47 19 48 82 15 < 0.05 PCR-RFLP
Yang 2010 China Asian wet 109 150 HB 31 45 33 30 50 70 < 0.05 PCR-RFLP
Chen 2008 USA Caucasian AMD 776 294 HB 131 400 245 10 128 156 < 0.05 Sequencing
Zeng 2011 China Caucasian AMD 1335 509 PB 244 641 450 21 181 307 0.374 SNaPshot
Li 2015 China Asian AMD 146 145 HB 73 54 19 44 74 27 0.674 MassARRAY MALDI-TOF
Yang 2018 China Asian AMD 201 201 HB 103 74 24 42 100 59 0.975 MassARRAY MALDI-TOF
Matuskova 2020 Czech Republic Caucasian wet 307 191 HB 69 148 90 9 66 116 0.921 SNaPshot Multiplex-System
Fritsche 2008 Germany Caucasian AMD 760 549 PB 152 344 264 22 174 353 0.923 Multiplex PCR
  1. HB hospital-based; PB population-based; SOC source of control; PCR-RFLP polymerase chain reaction followed by restriction fragment length polymorphism; RT-PCR real-time PCR; MALDI-TOF polymerase chain reaction–matrix-assisted laser desorption/ionization time-of-flight; HWE Hardy–Weinberg equilibrium of control group
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BMC Medical Genetics

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