Fig. 3

Plots of \( \ln {\hat{LR}}_W \) for the associations between rare variants around APOE (± 10 M bp) located on chromosome 19 and log-transformed CSF amyloid β 1–42 levels in ADNI. Positive \( \ln {\hat{LR}}_W \) represents test statistics for \( {\hat{\mu}}_{W_{+}}>{\hat{\mu}}_{W_{-}} \) and negatives for \( {\hat{\mu}}_{W_{+}}<{\hat{\mu}}_{W_{-}} \)