Table 1 Single nucleotide polymorphisms included in this study
Gene | SNP | Chrom | Genomic region | Functional effect |
|---|---|---|---|---|
TLR2 | rs4696480T > A | 4 | Intron | ↓transcriptional activity |
TLR2 | rs3804099C > T | 4 | Exon | ↓protein activity |
TLR2 | rs1816702C > T | 4 | Intron | ↑protein levels |
TLR4 | rs1554973C > T | 9 | 3’UTR | ↓transcriptional activity |
TLR4 | rs2737190G > A | 9 | 5’UTR | ↑transcriptional activity |
TLR4 | rs10759932T > C | 9 | Promoter | ↑transcriptional activity |
TLR4 | rs7856729G > T | 9 | 3’UTR | Not known |
TLR7 | rs179008A > T | X | Exon | ↓protein activity |
TLR9 | rs352139T > C | 3 | Intron | ↑transcriptional activity |
TLR9 | rs5743836A > G | 3 | Promoter | ↓transcriptional activity |
TLR9 | rs187084A > G | 3 | Promoter | ↓transcriptional activity |
TLR9 | rs352140C > T | 3 | Exon | Not known |
IL-6 | rs10499563T > C | 7 | Promoter | ↑transcriptional activity |
IL-6R | rs4537545T > C | 1 | Intron | Not known |
IL-10 | rs1800872G > T | 1 | Promoter | ↑transcriptional activity |
IL-10 | rs1878672G > C | 1 | Intron | ↑susceptibility to infection |
IL-28B | rs12979860T > C | 19 | Intron | ↓protein activity |
IFNAR1 | rs2843710C > G | 21 | 5’UTR | ↓transcriptional activity |
IFNAR1 | rs113181057T > C | 21 | Exon | ↓protein activity |
IL-1A | rs1800587T > C | 2 | 5’UTR | ↑transcriptional activity |