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Table 5 Synergistically combined genotype frequencies of TNF-α-308 G/A and INF-γ 874 A/T in different species of leishmaniasis and healthy human controls

From: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis

 L. major
102 (%)
Healthy human controls 
199 (%)
P valueOR (95%CI)
TNF-α 308 G/A
 Low (GG)60 (58.8)130 (65.3)  
 High (GA + AA)42 (41.2)69 (34.7)  
INF-γ 874 A/T
 Low (AA)28 (27.5)76 (38.2)  
 High (AT+TT)74 (72.5)123 (61.8)  
TNF-α with INF-γ
 Low/ low18 (17.6)51 (25.6)0.10.6 (0.3 to1.1)
 Low/ high42 (41.2)89 (44.7)0.50.8 (0.5 to 1.4)
 High/ low10 (9.8)25 (12.6)0.40.7 (0.3 to 1.6)
 High/ high32 (31.4)34 (17.1)P** 0.0052.2 (1.2 to 3.8)
 L. tropica
59 (%)
Healthy human controls 
199 (%)
  
TNF-α 308 G/A
 Low (GG)35 (59.3)130 (65.3)  
 High (GA + AA)24 (40.7)69 (34.7)  
INF-γ 874 A/T
 Low (AA)18 (30.5)76 (38.2)  
 High (AT+TT)41 (69.5)123 (61.8)  
TNF-α 308 / INF-γ 874
 Low/ low15 (25.4)51 (25.6)0.70.8 (0.3 to 1.7)
 Low/ high20 (33.9)89 (44.7)0.10.6 (0.3 to 1.1)
 High/ low3 (5.1)25 (12.6)0.10.3 (0.1 to 1.3)
 High/ high21 (35.6)34 (17.1)P** 0.0032.7 (1.4 to 5.1)
 Totalleishmaniacases 169 (%)Healthy human controls
199 (%)
  
TNF-α 308 G/A
 Low (GG)100 (59.2)130 (65.3)  
 High (GA + AA)69 (40.8)69 (34.7)  
INF-γ 874 A/T
 Low (AA)49 (29.0)76 (38.2)  
 High (AT+TT)120 (71.0)123 (61.8)  
TNF-α 308 / INF-γ 874
 Low/ low36 (21.3)51 (25.6)0.30.7 (0.4 to 1.2)
 Low/ high64 (37.9)89 (44.7)0.10.7 (0.4 to 1.1)
 High/ low15 (8.9)25 (12.6)0.20.6 (0.3 to 1.3)
 High/ high54 (31.9)34 (17.1)P** 0.0012.2 (1.2 to 3.7)
  1. P** highly significant